Clinical and Experimental Hepatology

Abstract

4/2021 vol. 7
Original paper

Von Willebrand factor and esophageal varices in children with chronic liver diseases

Mohamed Abdel-Salam El-Guindi 1
,
Nermin Mohammed Adawy 1
,
Iman Shaban Osheba 2
,
Wafaa Masoud Khalifa 3
,
Hosam Eldin Mohammed Basiouny 1
  1. Department of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Shebin El-koom, Menoufia, Egypt
  2. Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebin El-koom, Menoufia, Egypt
  3. Department of Pediatrics, Mahalet Marhom hospital, Algharbeia, Ministry of Health and Population, Egypt
Clin Exp HEPATOL 2021; 7, 4: 429-436
DOI: https://doi.org/10.5114/ceh.2021.109672
Online publish date: 2021/12/23
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Introduction

To evaluate the role of plasma level of von Willebrand factor antigen (vWF-Ag) as a possible predictor for the presence of esophageal varices (EVs) in children with chronic liver diseases (CLDs).

Material and methods

All patients underwent upper esophagogastroduodenoscopy (EGD) and were categorized as group I (had EVs) and group II (had no EVs). The following patient data were determined: Child-Pugh score (CPS), plasma vWF-Ag, vWF-Ag/thrombocyte ratio (VITRO) score, aspartate transaminase (AST) to platelet ratio index (APRI) score, AST/alanine transaminase (ALT), platelet count/spleen diameter, grading of EVs (small, medium and large) and categorizing the stage of liver fibrosis.

Results

The analysis included 50 patients with CLD; 30 (60%) were female. The commonest etiological diagnoses were autoimmune hepatitis (AIH) (20%) and extra-hepatic biliary atresia (EHBA) (12%). 26% of cases were categorized as undiagnosed CLD. The CPS showed CPS-A 34%, CPS-B 44% and CPS-C 22%. The vWF-Ag was found at a high level of 243.52 ±195.97, with a highly statistically significant difference in discriminating the EVs with 74% accuracy at a cut-off value of 108.99 IU/ml, p < 0.0001. Also, ROC analysis was performed for discriminating large esophageal varices with 84% accuracy at a cut-off value of 475.85 mg%. The VITRO score at a cut-off value of 1.72 could detect EVs with 70% sensitivity, 86.7% specificity, and 80% accuracy.

Conclusions

High vWF-Ag is a valuable prognostic tool for estimating the presence of EVs, and higher vWF-Ag is associated with increased grade of EVs.

Keywords

chronic liver diseases, von Willebrand factors, esophageal varices

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