eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Journal's reviewers Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
5/2021
vol. 38
 
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abstract:
Original paper

Wound coverage by the linen dressing accelerates ulcer healing

Katarzyna Skórkowska-Telichowska
1
,
Justyna Mierziak-Darecka
2
,
Magdalena Wrobel-Kwiatkowska
3
,
Tomasz Gebarowski
4
,
Jan Szopa
2, 5
,
Magdalena Zuk
2, 5

1.
Department of Endocrinology and Department of Dermatology, IV Clinical Military Hospital, Wroclaw, Poland
2.
Faculty of Biotechnology, Wroclaw University, Wroclaw, Poland
3.
Department of Biotechnology and Food Microbiology, Faculty of Biotechnology and Food Sciences, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
4.
Faculty of Pharmacy, Department of Basic Medical Sciences, Wroclaw Medical University, Wroclaw, Poland
5.
Linum Foundation, Wroclaw, Poland
Adv Dermatol Allergol 2021; XXXVIII (5): 827-841
Online publish date: 2021/11/05
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Introduction
Chronic ulcers are the main cause of morbidity and mortality, and the incidence of chronic wounds is expected to increase given that people live longer and that there are civil diseases. Much attention in the treatment of wounds concerns a dressing that involves wound cleansing, bacterial balance, exudate management and local tissue in a wound environment. These important elements of the evaluation led to the development of an interactive dressing based entirely on flax raw materials.

Material and methods
The complete dressing for wound coverage was prepared from plant (flax) row products: seedcakes, oil, fiber. The content of bioactive compounds (qualitatively and quantitatively) was tested using chromatographic techniques, and their biological activity during tests on fibroblast cell cultures (NHDF). As a final step the clinical trial were performed.

Results
The dressings, which help control the microenvironment, combining with exudate using hydrophilic fibre, controlling the flow of exudate from the wound to the dressing were generated. They stimulate the activity in the healing cascade and accelerate the healing process by combining lignocellulose fibre with higher amounts of phenolic compounds, sterols, cannabidiol and unsaturated fatty acids simultaneously with the 3-hydroxybutyrate polymer. All constituents of linen dressing are natural, originate from two types of the engineered flax plant. Pre-clinical data reveal a reasonable reduction in wound size in patients with chronic leg ulcers treated with a linen dressing.

Conclusions
For the first time, a successful application of the innovative interactive linen dressing in the treatment of chronic wounds was noted.

keywords:

chronic wounds, polyhydroxybutyrate, skin ulceration, wound dressing

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