Abstract
Association of vitamin D receptor gene polymorphisms with risk of cutaneous melanoma. A meta-analysis based on 40 case-control studies
- Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
- Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
- Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
- Department of Biology, Science and Arts University, Yazd, Iran
- Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
- Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Introduction
Previous studies on the association of vitamin D receptor (VDR) gene polymorphisms with cutaneous melanoma risk reported conflicting results.
Objective
To obtain a more precise assessment of the associations, we performed a meta-analysis of previously published studies.
Material and methods
We searched for eligible studies in the PubMed, Embase, and CNKI databases. A total of 40 case-control studies with 1,144 cases and 2,925 controls were included.
Results
The pooled analyses suggested a significant association between the FokI C>T and BsmI G>A polymorphisms of the VDR gene and susceptibility to melanoma. However, we found that the VDR TaqI T>C, EcoRV A>G, ApaI G>T, and Cdx2 G>A polymorphisms were not associated with melanoma risk.
Conclusions
The meta-analysis suggests that VDR FokI C>T and BsmI G>A polymorphisms are significantly associated with melanoma risk, while TaqI T>C, EcoRV A>G, ApaI G>T, and Cdx2 G>A polymorphisms are not associated with melanoma risk.
Keywords
cutaneous melanoma, vitamin D receptor, polymorphism, meta-analysis
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