eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
1/2012
vol. 16
 
Share:
Share:
abstract:
Case report

Effective therapeutic management of hepatocellular carcinoma – on the basis of a clinical case
[Polish version: Skuteczne postępowanie terapeutyczne w nieresekcyjnym raku wątrobowokomórkowym – na przykładzie przypadku klinicznego p. 64]

Joanna Omyła-Staszewska
,
Andrzej Deptała

Wspolczesna Onkol 2012; 16 (1): 60–63
[Polish version: Wspolczesna Onkol 2012; 16 (1): 64–67]
Online publish date: 2012/02/29
View full text Get citation
 
PlumX metrics:
The prognosis of patients suffering from primary hepatocellular carcinoma (HCC) is unfavourable because the tumour usually develops in cirrhosis-affected liver and is typically not diagnosed until an advanced stage of the disease. The 5-year survival rate for HCC patients in Europe does not exceed 9%. On the basis of a clinical case, the present article discusses the strategy of treatment of HCC patients. Patients with advanced HCC, stage C according to the Barcelona Clinic Liver Cancer (BCLC) staging system, typically receive systemic chemotherapy with sorafenib. The standard management in the treatment of intermediate-stage HCC, i.e. BCLC’s stage B, is chemoembolization (TACE). However, repeated TACE sessions activate factors involved in the process of angiogenesis such as hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF), which can render the procedure ineffective. Therefore, there are scientific foundations for combining TACE with antiangiogenic agents such as sorafenib. Results of studies conducted to date indicate that the combination of sorafenib with TACE in patients with BCLC’s stage B brings tangible therapeutic effects while being safe. The value of this therapeutic strategy is confirmed by the case described below, in which TACE + sorafenib have induced a partial regression of HCC.
keywords:

hepatocellular carcinoma, HCC, sorafenib, TACE

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.