eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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SCImago Journal & Country Rank
 
5/2005
vol. 4
 
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abstract:

Cimicifuga racemosa as floral Selective Estrogen Receptor Modulator

Paweł Bodera
,
Sebastian Poznański

Prz Menopauz 2005; 5: 32–36
Online publish date: 2005/11/02
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Selective Estrogen Receptor Modulators (SERMs) are characterized by their ability to act as either estrogen agonists or antagonists in different tissues, with different genes, and in different hormonal milieux. The effects of the SERMs are partially understood by their interactions with the ligand binding pocket of the estrogen receptors (ER) a and b. Extracts of Black cohosh (Cimicifuga racemosa) have been used for the treatment of climacteric complaints since decades. Efficacy, particularly concerning neurovegetative and psychic symptoms, has been proven in clinical trials. A unknown substances with Selective Estrogen Receptor Modulator (SERM) activity as active principle have been assumed. Recently, evidence arose that Cimicifuga racemosa may also contain dopaminergic compounds, which may contribute to the therapeutic activity of the extract.
keywords:

Black cohosh (Cimicifuga racemosa), estrogen receptor, Selective Estrogen Receptor Modulator (SERM), neurovegetative and psychic symptoms relief

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