eISSN: 2083-8441
ISSN: 2081-237X
Pediatric Endocrinology Diabetes and Metabolism
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1/2021
vol. 27
 
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abstract:
Review paper

β-cell self-destruction and extremely complicated and still unknown etiopathogenesis of type 1 diabetes

Artur Chwalba
1
,
Aleksandra Pilśniak
2
,
Ewa Otto-Buczkowska
3

1.
Department of Pharmacology, Medical University of Silesia, Poland
2.
Inpatient Department of Radiation and Clinical Oncology, Maria Skłodowska-Curie Institute – Oncology Center, Gliwice Branch, Poland
3.
Medical Specialist Centre in Gliwice, Medical Specialist Centre in Gliwice, Poland
Pediatr Endocrinol Diabetes Metab 2021; 27 (1): 47–50
Online publish date: 2021/02/11
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Type 1 diabetes is based on apoptosis, which leads to b-cell death. Factors triggering apoptosis processes are very diverse and currently not fully explained. The main role is attributed to genetic and environmental factors. Genetic studies have shown that the inherited propensity for type 1 diabetes is multi-genetic. Environmental factors modify the response to their own antigens, but are probably not necessary to start the autoaggression process. The effect of b-cell destruction is confirmed by the appearance of autoantibodies in the blood. The paper presents a review of the available literature regarding the self-destruction of pancreatic b-cells. The aim of the study was to draw attention to the extremely complicated and still unknown etiopathogenesis of type 1 diabetes by reviewing current literature related to the above topic. The goal is to acquire the knowledge necessary to develop and implement causal treatment for diabetes. At the moment, unfortunately, we do not have safe, innovative therapy methods in the field of diabetes prevention. Intensive research on the etiopathogenesis of type 1 diabetes is an extremely important field of medical research.
keywords:

apoptosis, autoantibodies, type 1 diabetes, b-cell destruction, immunological markers

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