Postępy w Kardiologii Interwencyjnej

Abstract

1/2026 vol. 22
Original paper

A cross-sectional study on the impact of NLRP3 and FGF23 levels on atherosclerotic cardiovascular disease in elderly diabetic patients

Bin Luo 1
,
Ruifen Zhou 2
,
Bining Ye 1
  1. Department of Clinical Laboratory, Xianning Central Hospital, the First Affiliated Hospital of Hubei University of Science and Technology, Xianning, Hubei Province, China
  2. Department of Blood Transfusion, Xianning Central Hospital, the First Affiliated Hospital of Hubei University of Science and Technology, Xianning, Hubei Province, China
Adv Interv Cardiol 2026; 22, 1 (83): 41–47
DOI: https://doi.org/10.5114/aic.2026.160068
Online publish date: 2026/03/10
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Introduction

Atherosclerotic cardiovascular disease (ASCVD) is a major cause of mortality and disability in elderly patients with diabetes.

Aim

We aimed to investigate the impact of serum NOD-like receptor protein 3 (NLRP3) and fibroblast growth factor 23 (FGF23) on ASCVD in elderly diabetic patients.

Material and methods

A total of 130 elderly diabetic patients and 60 healthy controls were enrolled, and serum NLRP3 and FGF23 levels were measured. Logistic regression analysis and ROC curves were applied to assess the influencing factors.

Results

Fasting blood glucose and diabetes duration were higher or longer in the ASCVD group than in the diabetes group (all p < 0.001). The levels of NLRP3 and FGF23 were higher in the ASCVD group than in the diabetic group (all p < 0.001). Serum NLRP3, FGF23, fasting blood glucose, and duration of diabetes were independent influences on the occurrence of ASCVD in elderly diabetic patients (p = 0.001, < 0.001, 0.005, < 0.001). The AUC of the combined test was 0.887 (95% CI: 0.827–0.947), which was superior to that of the individual tests (NLRP3 AUC = 0.732 (95% CI: 0.646–0.818), FGF23 AUC = 0.861 (95% CI: 0.791–0.932)).

Conclusions

The levels of FGF23 and NLRP3 are associated with the occurrence and development of ASCVD in elderly diabetic patients. Elevated levels of NLRP3 and FGF23 may be influencing factors for ASCVD in elderly diabetic patients. The failure to include potential confounding factors such as eGFR is a major limitation of this study.

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Keywords

diabetes, atherosclerotic cardiovascular disease, NOD-like receptor protein 3, fibroblast growth factor 23, elderly

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