A new look on vitamin D – role in oncological disorders

Eleonora Mess; Wiktoria Pająk; Maciej Ornat

doi:10.5114/pm.2019.83841

eISSN: 2081-2833
ISSN: 2081-0016

Medycyna Paliatywna/Palliative Medicine

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1/2019
vol. 11

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abstract:

Review paper

A new look on vitamin D – role in oncological disorders

Eleonora Mess

¹

,

Wiktoria Pająk

¹

,

Maciej Ornat

²

Zakład Onkologii i Opieki Paliatywnej, Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

Zakład Histologii i Embriologii, Katedra Morfologii i Embriologii Człowieka, Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

Medycyna Paliatywna 2019; 11(1): 21–26

DOI: https://doi.org/10.5114/pm.2019.83841

Online publish date: 2019/03/25

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Molecules from vitamin D group belong to organic, lipid-soluble substances classifed as secosteroids which are characterized by cleavage of the B ring of the core structure. Vitamin D receptors are localized on cells in many different types of tissues and organs which makes vitamin D has pleiotropic functions and influences on functioning of whole body and modifies course of different diseases. Calcitriol affects the biology of cells with two different pathways: genomic and non-genomic actions. Results of many surveys suggest the correlation between vitamin D concentration and risk of many different tumors. Vitamin D deficiency can play role in breast cancer, prostate cancer, colorectal cancer or malignant melanoma. Furthermore, vitamin D is crucial for calcium and phosphate homeostasis and it’s deficiency may cause musculoskeletal, cardiovascular and respiratory disorders.

keywords:

A new look on vitamin D – role in oncological disorders

Eleonora Mess 1 , Wiktoria Pająk 1 , Maciej Ornat 2

vitamin D, oncological disorders

Eleonora Mess

¹

,

Wiktoria Pająk

¹

,

Maciej Ornat

²