A paradigm of higher success rate of intracytoplasmic sperm injection – preovulatory human chorionic gonadotropin-day
serum oestradiol

Ahmed Elsayad; Wael Khafagy; Walaa ElBassioune; Mahmoud Rady; Ahmed Abdeltawab; Muhammad Altoraky; Mahmoud Hegazy; Waled Ayad; Moatazza Alghazaly; Ahmed Elshorbagy; Ahmed Shafik Almorsy; Ahmed Saeed; Elmetwally Farouk; Ehab Elhelw; Hamada Abuelmatti; Mohammed El-Husseny Elkadosi

doi:10.5114/pm.2023.127964

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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2/2023
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Original paper

A paradigm of higher success rate of intracytoplasmic sperm injection – preovulatory human chorionic gonadotropin-day serum oestradiol

Ahmed Elsayad

¹

,

Wael Khafagy

²

,

Walaa ElBassioune

²

,

Mahmoud Rady

²

,

Ahmed Abdeltawab

²

,

Muhammad Altoraky

²

,

Mahmoud Hegazy

²

,

Waled Ayad

²

,

Moatazza Alghazaly

²

,

Ahmed Elshorbagy

²

,

Ahmed Shafik Almorsy

²

,

Ahmed Saeed

²

,

Elmetwally Farouk

²

,

Ehab Elhelw

²

,

Hamada Abuelmatti

²

,

Mohammed El-Husseny Elkadosi

¹

Department of Obstetrics and Gynaecology, Zagazig University, Egypt
Department of Obstetrics and Gynaecology, Al-Azhar University, Egypt

Menopause Rev 2023; 22(2): 83-86

DOI: https://doi.org/10.5114/pm.2023.127964

Online publish date: 2023/06/14

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AMA

Elsayad A, Khafagy W, ElBassioune W, et al. A paradigm of higher success rate of intracytoplasmic sperm injection – preovulatory human chorionic gonadotropin-day
serum oestradiol. Menopause Review/Przegląd Menopauzalny. 2023;22(2):83-86. doi:10.5114/pm.2023.127964.

APA

Elsayad, A., Khafagy, W., ElBassioune, W., Rady, M., Abdeltawab, A.,  & Altoraky, M. et al. (2023). A paradigm of higher success rate of intracytoplasmic sperm injection – preovulatory human chorionic gonadotropin-day
serum oestradiol. Menopause Review/Przegląd Menopauzalny, 22(2), 83-86. https://doi.org/10.5114/pm.2023.127964

Chicago

Elsayad, Ahmed, Wael Khafagy, Walaa ElBassioune, Mahmoud Rady, Ahmed Abdeltawab, Muhammad Altoraky,  and Mahmoud Hegazy et al. 2023. "A paradigm of higher success rate of intracytoplasmic sperm injection – preovulatory human chorionic gonadotropin-day
serum oestradiol". Menopause Review/Przegląd Menopauzalny 22 (2): 83-86. doi:10.5114/pm.2023.127964.

Harvard

Elsayad, A., Khafagy, W., ElBassioune, W., Rady, M., Abdeltawab, A., Altoraky, M., Hegazy, M., Ayad, W., Alghazaly, M., Elshorbagy, A., Shafik Almorsy, A., Saeed, A., Farouk, E., Elhelw, E., Abuelmatti, H.,  and Elkadosi, M. (2023). A paradigm of higher success rate of intracytoplasmic sperm injection – preovulatory human chorionic gonadotropin-day
serum oestradiol. Menopause Review/Przegląd Menopauzalny, 22(2), pp.83-86. https://doi.org/10.5114/pm.2023.127964

MLA

Elsayad, Ahmed et al. "A paradigm of higher success rate of intracytoplasmic sperm injection – preovulatory human chorionic gonadotropin-day
serum oestradiol." Menopause Review/Przegląd Menopauzalny, vol. 22, no. 2, 2023, pp. 83-86. doi:10.5114/pm.2023.127964.

Vancouver

Elsayad A, Khafagy W, ElBassioune W, Rady M, Abdeltawab A, Altoraky M et al. A paradigm of higher success rate of intracytoplasmic sperm injection – preovulatory human chorionic gonadotropin-day
serum oestradiol. Menopause Review/Przegląd Menopauzalny. 2023;22(2):83-86. doi:10.5114/pm.2023.127964.

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Introduction
The aim of the study is to evaluate the correlation between the level of serum oestradiol (E2) on the day of human chorionic gonadotropin (hCG-day) administration and successful intracytoplasmic sperm injection (ICSI) outcome.

Material and methods
This prospective study was performed during the period from January 2019 to September 2021, at Zagazig Obstetrics and Gynecology Department, and Al-Azhar Obstetrics and Gynecology Department, and private ART centers. One hundred and fifty women attending the infertility clinic for ICSI cycles. All women were divided into 5 groups according to the serum E2 level on the day of hCG administration: Group A – serum E2 < 1000 pg/ml; Group B – serum E2 1000 to < 2000 pg/ml; Group C – serum E2 2000 to < 3000 pg/ml;Group D – serum E2 3000 to < 4000 pg/ml; Group E – serum E2 ≥ 4000 pg/ml.

Results
The highest fertilization rate (58.1%) was among women with E2 ≥ 4000 pg/ml, while the lowest (37%) was in women with E2 1000 to < 2000 pg/ml. Also, the highest pregnancy rate (21.5%) was among women with E2 > 4000 pg/ml, while the lowest (5.3%) was in women with E2 < 1000 pg/ml. In the current study the median serum E2 level on the day of hCG administration was highly significant in women who became pregnant when compared to women who did not. The best cut-off value of serum E2 at hCG administration was ≥ 3682.3 pg/ml.

Conclusions
this study suggests that the optimal range of E2 level for achieving a successful pregnancy is > 4000 pg/ml.

keywords:

A paradigm of higher success rate of intracytoplasmic sperm injection – preovulatory human chorionic gonadotropin-day serum oestradiol

preovulatory hCG, serum oestradiol, intracytoplasmic sperm injection