Abstract
5/2005
vol. 43
REVIEW PAPERAnti-ribosomal P protein antibodies: clinical significance and role in pathogenesis of systemic lupus erythematosus
Ru 2005, 43; 5: 274-279
Online publish date: 2005/10/27
Ribosomal P protein is a pentamere composed of 3 phosphoproteins: P0, P1 and P2 with molecular weights, respectively: 38, 19 i 17 kDa.
Their function is not exactly known, it is supposed that are essential for all 3 stages of protein synthesis and for regulation of ribosomal GTP activity.
Anti-P antibodies react to at least 1 epitope common to all 3 proteins and corresponding to a single sequential antigenic determinant present in the carboxyl-terminal 22-amino-acid sequence. ELISA and immunoblotting are used in detection of anti-P antibodies.
There is a wide variation in the reported prevalence of these antibodies in SLE patients. Some authors found it in 5-10% but the others revealed anti-P in 42% of SLE patients.
It has been reported that anti-ribosomal P antibodies correlate with high activity SLE, risk of CNS or renal involvement and hepatic or haematologic complications.
Their function is not exactly known, it is supposed that are essential for all 3 stages of protein synthesis and for regulation of ribosomal GTP activity.
Anti-P antibodies react to at least 1 epitope common to all 3 proteins and corresponding to a single sequential antigenic determinant present in the carboxyl-terminal 22-amino-acid sequence. ELISA and immunoblotting are used in detection of anti-P antibodies.
There is a wide variation in the reported prevalence of these antibodies in SLE patients. Some authors found it in 5-10% but the others revealed anti-P in 42% of SLE patients.
It has been reported that anti-ribosomal P antibodies correlate with high activity SLE, risk of CNS or renal involvement and hepatic or haematologic complications.
Keywords
anti-ribosomal P protein antibodies, systemic lupus erythematosus
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