eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
3/2009
vol. 13
 
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abstract:
Case report

Acute myeloid leukaemia in a patient with AIDS – case report

Elżbieta Kisiel
,
Piotr Centkowski
,
Krzysztof Warzocha
,
Regina B. Podlasin

Współczesna Onkologia (2009) vol. 13; 3 (144-149)
Online publish date: 2009/07/23
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HIV-infected subjects are at increased risk of developing several cancers. Three of them – Kaposi’s sarcoma, non-Hodgkin’s lymphoma and invasive cervical cancer – are accepted as AIDS-defining malignancies. Acute myeloproliferative diseases are rare in HIV-infected individuals. HIV-seropositive patients with acute myeloid leukaemia (AML) are presented in the literature as isolated case reports. We describe a case of acute myeloid leukaemia (FAB-M5a) with Kaposi’s sarcoma occurring in a HIV/EBV coinfected woman, sequentially treated with highly active antiretroviral therapy (ARV). She received treatment with a standard AML induction regimen consisting of infusion of cytarabine 200 mg/m2 daily for 5 days, etoposide 100 mg daily for 5 days and idarubicin 10 mg/m2 daily for 3 days, followed by double consolidation chemotherapy (I – cytarabine + mitoxantrone, II HD cytarabine). Complete remission (CR) lasting six months was achieved. HIV viral load increase was not observed. CD4+ cell count has remained above 200/µl. ARV has resulted in a significant decline of mortality and opportunistic infections, improving overall survival among HIV-infected patients. Conventional chemotherapy regimens often followed by haematopoietic stem cell transplantation have become commonly used. As acute myeloid leukaemia is rare in HIV-infected individuals, recommendations on treatment have not been defined and each case is treated individually.
keywords:

human immunodeficiency virus (HIV), acute myeloid leukaemia (AML), chemotherapy, highly active antiretroviral therapy

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