eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
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1/2016
vol. 12
 
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Acute myocardial infarction due to coronary embolism originating from left ventricle thrombus in a patient with dilated cardiomyopathy and sinus rhythm

Małgorzata Zachura
,
Marcin Sadowski
,
Agnieszka Janion-Sadowska
,
Jacek Kurzawski
,
Marianna Janion

Adv Interv Cardiol 2016; 12, 1 (43): 73–74
Online publish date: 2016/02/11
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Coronary artery embolism causing acute myocardial infarction (AMI) is more common than previously thought. Prizel et al. observed coronary artery embolic infarcts in 55 out of 419 patients, which comprised 13% of autopsy-studied infarcts [1]. The large diversity of etiologies makes the precise diagnosis challenging.
A 46-year-old male cigarette smoker was admitted to the emergency department due to sudden severe chest pain. He had a history of arterial hypertension, hypercholesterolemia and heart failure in New York Heart Association (NYHA) functional class III due to post-inflammatory dilated cardiomyopathy, diagnosed in 2007. He was previously treated with loop diuretics, angiotensin-converting-enzyme inhibitor (ACEI) and B-adrenolytic. Laboratory tests on admission revealed significantly elevated markers of myocardial necrosis (high sensitivity troponin T level up to 1766 ng/l) and a high level of plasma B-type natriuretic peptide (1801 pg/ml). Electrocardiography (ECG) showed left bundle branch block (LBBB). Transthoracic echocardiography (TTE) examination revealed a significant reduction of left ventricular ejection fraction (LVEF) of 14% with diffuse global hypokinesis, an akinetic anterior wall and the presence of a mobile thrombus in the left ventricle (Figure 1 A). Urgent coronary angiography showed distal occlusion of the left anterior descending coronary artery (LAD) by a well-organized thrombus and no atherosclerotic lesions in the coronary arteries (Figure 1 B). Because of the very distal location of the thrombus, manual aspirational thrombectomy was not feasible. Percutaneous coronary intervention (PCI) was also rejected due to the small diameter of the vessel. The patient was qualified for conservative treatment. Low molecular weight heparin (LMWH) was administered followed by oral anticoagulant until the international normalized ratio (INR) was in the therapeutic range. The patient also received acetylsalicylic acid and standard heart failure treatment.
During hospitalization, dynamic changes in the shape and mobility of the gradually resorbing thrombus were observed in the echocardiographic images. After 6 weeks of anticoagulation therapy TTE showed the absence of a thrombus in the LV and revealed the improvement of LVEF from 14% at baseline to 23% (Figure 1 C).
In many cardiac conditions the risk of thromboembolic events is a reason for concern. The most common causes of coronary artery embolism are valvular heart...


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