Advancements and future directions of iron oxide nanoparticles in cancer therapy

Ahmed el-Mallul; Ryszard Tomasiuk; Piotr Jaworski; Sadia Mughali

doi:10.5114/wo.2025.155978

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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4/2025
vol. 29

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abstract:

Review paper

Advancements and future directions of iron oxide nanoparticles in cancer therapy

Ahmed el-Mallul

¹

,

Ryszard Tomasiuk

¹

,

Piotr Jaworski

¹

,

Sadia Mughali

²

University of Radom, Faculty of Medical Sciences and Health Sciences, Radom, Poland
Bahria University Medical and Dental College (BUMDC), Department of Medicine, Karachi, Pakistan

Contemp Oncol (Pozn) 2025; 29 (4): 323–332

DOI: https://doi.org/10.5114/wo.2025.155978

Online publish date: 2025/11/05

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Cancer is one of the leading causes of death worldwide, accounting for approximately 9.6 million deaths annually – 1 in 6 deaths globally. Recent advancements in nanoscience have highlighted the potential of nanomaterials in healthcare applications. Among these, iron oxide nanoparticles (IONPs) stand out due to their magnetic properties, semiconductor behavior, biocompatibility, biodegradability, and low toxicity. These characteristics make them highly valuable in multifunctional biomedical applications, including: magnetic hyperthermia for cancer therapy; targeted drug delivery to minimize chemotherapy side effects; cell labeling and tracking; and bioimaging techniques. This mini-review focuses on the latest developments in IONPs for cancer therapy, evaluating recent research on size, synthesis methods, and biomedical/electrochemical applications of coated, drug-loaded, and targeted nanoparticles. By compiling and comparing key findings, this paper serves as a comprehensive reference for researchers and scientists working on the multidisciplinary applications of nanomaterials.

keywords:

Advancements and future directions of iron oxide nanoparticles in cancer therapy

Ahmed el-Mallul 1 , Ryszard Tomasiuk 1 , Piotr Jaworski 1 , Sadia Mughali 2

cancer, iron, neoplasms, electric stimulation therapy, adrenergic agents

Ahmed el-Mallul

¹

,

Ryszard Tomasiuk

¹

,

Piotr Jaworski

¹

,

Sadia Mughali

²