Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol
in patients undergoing thyroidectomy

Francesk Mulita; Georgios-Ioannis Verras; Fotios Iliopoulos; Charalampos Kaplanis; Elias Liolis; Levan Tchabashvili; Christos Tsilivigkos; Ioannis Perdikaris; Argyro Sgourou; Adamantia Papachatzopoulou; Ioannis Maroulis

doi:10.5114/pm.2021.110955

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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4/2021
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abstract:

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Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol in patients undergoing thyroidectomy

Francesk Mulita

¹

,

Georgios-Ioannis Verras

¹

,

Fotios Iliopoulos

¹

,

Charalampos Kaplanis

¹

,

Elias Liolis

²

,

Levan Tchabashvili

¹

,

Christos Tsilivigkos

¹

,

Ioannis Perdikaris

¹

,

Argyro Sgourou

³

,

Adamantia Papachatzopoulou

⁴

,

Ioannis Maroulis

¹

Department of Surgery, General University Hospital of Patras, Greece
Department of Internal Medicine, Division of Oncology, General University Hospital of Patras, Greece
Biology Laboratory, School of Science and Technology, Hellenic Open University, Patras, Greece
Laboratory of General Biology, Medical Faculty, University of Patras, Patras, Greece

Menopause Rev 2021; 20(4): 226-230

DOI: https://doi.org/10.5114/pm.2021.110955

Online publish date: 2021/11/24

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AMA

Mulita F, Verras G, Iliopoulos F, et al. Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol
in patients undergoing thyroidectomy. Menopause Review/Przegląd Menopauzalny. 2021;20(4):226-230. doi:10.5114/pm.2021.110955.

APA

Mulita, F., Verras, G., Iliopoulos, F., Kaplanis, C., Liolis, E.,  & Tchabashvili, L. et al. (2021). Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol
in patients undergoing thyroidectomy. Menopause Review/Przegląd Menopauzalny, 20(4), 226-230. https://doi.org/10.5114/pm.2021.110955

Chicago

Mulita, Francesk, Georgios-Ioannis Verras, Fotios Iliopoulos, Charalampos Kaplanis, Elias Liolis, Levan Tchabashvili,  and Christos Tsilivigkos et al. 2021. "Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol
in patients undergoing thyroidectomy". Menopause Review/Przegląd Menopauzalny 20 (4): 226-230. doi:10.5114/pm.2021.110955.

Harvard

Mulita, F., Verras, G., Iliopoulos, F., Kaplanis, C., Liolis, E., Tchabashvili, L., Tsilivigkos, C., Perdikaris, I., Sgourou, A., Papachatzopoulou, A.,  and Maroulis, I. (2021). Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol
in patients undergoing thyroidectomy. Menopause Review/Przegląd Menopauzalny, 20(4), pp.226-230. https://doi.org/10.5114/pm.2021.110955

MLA

Mulita, Francesk et al. "Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol
in patients undergoing thyroidectomy." Menopause Review/Przegląd Menopauzalny, vol. 20, no. 4, 2021, pp. 226-230. doi:10.5114/pm.2021.110955.

Vancouver

Mulita F, Verras G, Iliopoulos F, Kaplanis C, Liolis E, Tchabashvili L et al. Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol
in patients undergoing thyroidectomy. Menopause Review/Przegląd Menopauzalny. 2021;20(4):226-230. doi:10.5114/pm.2021.110955.

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Introduction
The purpose of this study was to investigate the analgesic effect of 3 different regimens of combination analgesics administered to patients undergoing thyroidectomy.

Material and methods
A total of 152 patients undergoing total or subtotal thyroidectomy were enrolled. Patients allocated to group A received a combination of intravenous (IV) paracetamol and intramuscular (IM) pethidine, patients in group B received a combination of IV paracetamol and IV parecoxib, while patients in group C received IV paracetamol monotherapy.

Results
The analgesic regimens of groups A and B were found to be of equivalent efficacy (p-value = 1.000). In contrast, patients in group C (paracetamol monotherapy) had higher numerical rating scale scores, compared to both patients in groups A (p-value < 0.001) and B (p-value < 0.001).

Conclusions
The combinations of IV paracetamol with either IM pethidine or IV parecoxib are superior to IV paracetamol monotherapy in achieving pain control in patients undergoing thyroid surgery.

keywords:

Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol in patients undergoing thyroidectomy

Francesk Mulita 1 , Georgios-Ioannis Verras 1 , Fotios Iliopoulos 1 , Charalampos Kaplanis 1 , Elias Liolis 2 , Levan Tchabashvili 1 , Christos Tsilivigkos 1 , Ioannis Perdikaris 1 , Argyro Sgourou 3 , Adamantia Papachatzopoulou 4 , Ioannis Maroulis 1

pethidine, parecoxib, postoperative pain, pain assessment, thyroidectomy

Francesk Mulita

¹

,

Georgios-Ioannis Verras

¹

,

Fotios Iliopoulos

¹

,

Charalampos Kaplanis

¹

,

Elias Liolis

²

,

Levan Tchabashvili

¹

,

Christos Tsilivigkos

¹

,

Ioannis Perdikaris

¹

,

Argyro Sgourou

³

,

Adamantia Papachatzopoulou

⁴

,

Ioannis Maroulis

¹