Abstract
Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol in patients undergoing thyroidectomy
- Department of Surgery, General University Hospital of Patras, Greece
- Department of Internal Medicine, Division of Oncology, General University Hospital of Patras, Greece
- Biology Laboratory, School of Science and Technology, Hellenic Open University, Patras, Greece
- Laboratory of General Biology, Medical Faculty, University of Patras, Patras, Greece
Introduction
The purpose of this study was to investigate the analgesic effect of 3 different regimens of combination analgesics administered to patients undergoing thyroidectomy.
Material and methods
A total of 152 patients undergoing total or subtotal thyroidectomy were enrolled. Patients allocated to group A received a combination of intravenous (IV) paracetamol and intramuscular (IM) pethidine, patients in group B received a combination of IV paracetamol and IV parecoxib, while patients in group C received IV paracetamol monotherapy.
Results
The analgesic regimens of groups A and B were found to be of equivalent efficacy (p-value = 1.000). In contrast, patients in group C (paracetamol monotherapy) had higher numerical rating scale scores, compared to both patients in groups A (p-value < 0.001) and B (p-value < 0.001).
Conclusions
The combinations of IV paracetamol with either IM pethidine or IV parecoxib are superior to IV paracetamol monotherapy in achieving pain control in patients undergoing thyroid surgery.
Keywords
pethidine, parecoxib, postoperative pain, pain assessment, thyroidectomy
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