Clinical and Experimental Hepatology
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ISSN: 2392-1099
Clinical and Experimental Hepatology
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Original paper

Annexin A2 as a marker for hepatocellular carcinoma detection among patients with hepatitis C virus-related liver cirrhosis after HCV treatment using directly acting antivirals

Mohamed S. Shater
1
,
Amr A. Abd Elmoety
1
,
Yousri A. A. Rostom
1
,
Eman Z. Elkemary
1
,
Hyam M. Helal
1
,
Ahmed Kamal
1

  1. Alexandria University, Egypt
Clin Exp HEPATOL 2025; 11, 4
Online publish date: 2025/10/14
Article file
- Annexin.pdf  [0.12 MB]
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1. Rumgay H, Arnold M, Ferlay J, et al. Global burden of primary liver cancer in 2020 and predictions to 2040. J Hepatol 2022; 77: 1598-1606.
2. Ahn JC, Lee YT, Agopian VG, et al. Hepatocellular carcinoma surveillance: current practice and future directions. Hepatoma Res 2022; 8: 10.
3. Harris PS, Hansen RM, Gray ME, et al. Hepatocellular carcinoma surveillance: An evidence-based approach. World J Gastroenterol 2019; 25: 1550-1559.
4. El-Houseini ME, Ismail A, Abdelaal AA, et al. Role of TGF-β1 and C-kit mutations in the development of hepatocellular carcinoma in hepatitis C virus-infected patients: in vitro study. Biochemistry (Mosc) 2019; 84: 941-953.
5. Herrera-López EE, Guerrero-Escalera D, Aguirre-Maldonado I, et al. Annexins A2 and A5 are potential early biomarkers of hepatocarcinogenesis. Sci Rep 2023; 13: 6948.
6. Sun Y, Gao G, Cai J, et al. Annexin A2 is a discriminative serological candidate in early hepatocellular carcinoma. Carcinogenesis 2013; 34: 595-604.
7. Grindheim AK, Saraste J, Vedeler A. Protein phosphorylation and its role in the regulation of Annexin A2 function. Biochim Biophys Acta Gen Subj 2017; 1861 (11 Pt A): 2515-2529.
8. Tas F, Tilgen Yasasever C, Karabulut S, et al. Circulating annexin A2 as a biomarker in gastric cancer patients: correlation with clinical variables. Biomed Pharmacother 2015; 69: 237-241.
9. Lokman NA, Ween MP, Oehler MK, et al. The role of annexin A2 in tumorigenesis and cancer progression. Cancer Microenviron 2011; 4: 199-208.
10. Shaker MK, Abdel Fattah HI, Sabbour GS, et al. Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients. World J Hepatol 2017; 9: 469-476.
11. Reig M, Forner A, Rimola J, et al. BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update. J Hepatol 2022; 76: 681-693.
12. Gao Y, Lyu L, Feng Y, et al. A review of cutting-edge therapies for hepatocellular carcinoma (HCC): Perspectives from patents. Int J Med Sci 2021; 18: 3066-3081.
13. Volk ML, Hernandez JC, Su GL, et al. Risk factors for hepatocellular carcinoma may impair the performance of biomarkers: a comparison of AFP, DCP, and AFP-L3. Cancer Biomark 2007; 3: 79-87.
14. Park HJ, Kim SY. Imaging modalities for hepatocellular carcinoma surveillance: Expanding horizons beyond ultrasound. J Liver Cancer 2020; 20: 99-105.
15. Xu XH, Pan W, Kang LH, et al. Association of annexin A2 with cancer development (Review). Oncol Rep 2015; 33: 2121-2128.
16. Shang S, Plymoth A, Ge S, et al. Identification of osteopontin as a novel marker for early hepatocellular carcinoma. Hepatology 2012; 55: 483-490.
17. Elgezawy E, Khalaf M, Eldeen M, et al. P-022 Expression of circulating annexin A2 in hepatic diseases and hepatocellular carcinoma. Ann Oncol 2015; 26: iv6.
18. Galle PR, Foerster F, Kudo M, et al. Biology and significance of alpha-fetoprotein in hepatocellular carcinoma. Liver Int 2019; 39: 2214-2229.
19. Marrero JA, Feng Z, Wang Y, et al. Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma. Gastroenterology 2009; 137: 110-118.
20. Hanno AEFF, Abd El-Aziz FM, Deghady AA, et al. Role of annexin A2 and osteopontin for early diagnosis of hepatocellular carcinoma in hepatitis C virus patients. Egyp Liver J 2019; 9: 5.
21. Chi X, Jiang L, Yuan Y, et al. A comparison of clinical pathologic characteristics between alpha-fetoprotein negative and positive hepatocellular carcinoma patients from Eastern and Southern China. BMC Gastroenterol 2022; 22: 202.
22. Ibrahim A, Hashem M, Mostafa E, et al. Annexin A2 versus Afp as an efficient diagnostic serum marker for hepatocellular carcinoma. J Gastroenterol Hepatol Res 2013; 2: 780-785.
23. Zhang HJ, Yao DF, Yao M, et al. Expression characteristics and diagnostic value of annexin A2 in hepatocellular carcinoma. World J Gastroenterol 2012; 18: 5897-5904.
24. Liu Z, Ling Q, Wang J, et al. Annexin A2 is not a good biomarker for hepatocellular carcinoma in cirrhosis. Oncol Lett 2013; 6: 125-129.
25. Chen CY, Lin YS, Chen CH, et al. Annexin A2-mediated cancer progression and therapeutic resistance in nasopharyngeal carcinoma. J Biomed Sci 2018; 25: 30.
26. Mahdi AF, Malacrida B, Nolan J, et al. Expression of annexin A2 promotes cancer progression in estrogen receptor negative breast cancers. Cells 2020; 9: 1582.
27. Gomaa A, Gomaa M, Allam N, Waked I. Hepatitis C elimination in Egypt: Story of success. Pathogens 2024; 13: 681.
28. Kamal A, Mohsin AK, Matta C, et al. Tolloid-like 1 gene variant rs17047200, pretreatment FIB-4, ALBI and PALBI scores as predictors of hepatocellular carcinoma occurrence after directly acting antivirals. Clin Exp Hepatol 2022; 8: 330-334.
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