Autoimmune hepatitis: clinicopathological characteristics and histopathological diagnosis in the light of current views

Ewa Iżycka-Świeszewska; Natalia Walkusz; Piotr Zieliński; Katarzyna Sikorska

doi:10.5114/ceh.2025.148233

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Review paper

Autoimmune hepatitis: clinicopathological characteristics and histopathological diagnosis in the light of current views

Ewa Iżycka-Świeszewska

^{1, 2}

,

Natalia Walkusz

¹

,

Piotr Zieliński

³

,

Katarzyna Sikorska

^{3, 4}

Department of Pathomorphology, Copernicus PL, Gdansk, Poland
Department of Pathology and Neuropathology, Medical University of Gdansk, Poland
Division of Tropical and Parasitic Diseases, Medical University of Gdansk, Poland
Division of Tropical Medicine and Epidemiology, Medical University of Gdansk, Poland

Clin Exp HEPATOL 2025; 11, 1: 14-24

DOI: https://doi.org/10.5114/ceh.2025.148233

Online publish date: 2025/03/31

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The diagnosis of autoimmune hepatitis (AIH) is based on clinical criteria and histopathological findings. Interpretation of lesions observed in liver biopsy specimens, in cases of suspected AIH, requires correlation with clinical data and communication between hepatologists and pathologists. The diagnostic criteria have been modified over the years, and the latest guidelines were proposed in 2022. Implementation of the current recommendations improves diagnostic accuracy for autoimmune hepatitis and related pathologies. This article presents the clinicopathological characteristics of AIH and an overview of the histopathological diagnostic approach in the light of the modern guidelines.

keywords:

Autoimmune hepatitis: clinicopathological characteristics and histopathological diagnosis in the light of current views

Ewa Iżycka-Świeszewska 1, 2 , Natalia Walkusz 1 , Piotr Zieliński 3 , Katarzyna Sikorska 3, 4

autoimmune hepatitis, histopathological examination, diagnostic criteria

Ewa Iżycka-Świeszewska

^{1, 2}

,

Natalia Walkusz

¹

,

Piotr Zieliński

³

,

Katarzyna Sikorska

^{3, 4}