Clinical and Experimental Hepatology

Abstract

1/2025 vol. 11
Review paper

Autoimmune hepatitis: clinicopathological characteristics and histopathological diagnosis in the light of current views

Ewa Iżycka-Świeszewska 1, 2
,
Natalia Walkusz 1
,
Piotr Zieliński 3
,
Katarzyna Sikorska 3, 4
  1. Department of Pathomorphology, Copernicus PL, Gdansk, Poland
  2. Department of Pathology and Neuropathology, Medical University of Gdansk, Poland
  3. Division of Tropical and Parasitic Diseases, Medical University of Gdansk, Poland
  4. Division of Tropical Medicine and Epidemiology, Medical University of Gdansk, Poland
Clin Exp HEPATOL 2025; 11, 1: 14-24
DOI: https://doi.org/10.5114/ceh.2025.148233
Online publish date: 2025/03/31
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The diagnosis of autoimmune hepatitis (AIH) is based on clinical criteria and histopathological findings. Interpretation of lesions observed in liver biopsy specimens, in cases of suspected AIH, requires correlation with clinical data and communication between hepatologists and pathologists. The diagnostic criteria have been modified over the years, and the latest guidelines were proposed in 2022. Implementation of the current recommendations improves diagnostic accuracy for autoimmune hepatitis and related pathologies. This article presents the clinicopathological characteristics of AIH and an overview of the histopathological diagnostic approach in the light of the modern guidelines.

Keywords

autoimmune hepatitis, histopathological examination, diagnostic criteria

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