Diagnosis and management of chronic abdominal pain in peri- and postmenopausal women is a difficult clinical problem requiring a multidisciplinary approach. Numerous studies have helped in better understanding of the pathogenesis and pathophysiology of pain in these patients, however, the success requires intensive investigation by a general practitioner or a specific specialist, depending on the involved organ, who can interpret pain also in the context of the psychosocial situation of the patient.