Clinical and Experimental Hepatology

Abstract

2/2025 vol. 11
Original paper

Clinical characteristics and risk factors of metabolic dysfunction-associated steatotic liver disease in lean patients: results of the Polish Gallstone Surgery Registry

Iwona Gorczyca-Głowacka 1
,
Łukasz Nawacki 1
,
Magdalena Kołomańska 1
,
Robert Mazurkiewicz 1
,
Marcin Niżnik 2
,
Krzysztof Ratnicki 2
,
Małgorzata Czerniak 2
,
Piotr Myrcha 3
,
Maciej Bękarski 3
,
Joao Rocha-Neves 4
,
Juliana Pereira-Macedo 5
,
Kryspin Mitura 6
,
Laura Kacprzak 7
,
Małgorzata Pajer 7
,
Piotr Richter 8
,
Kamil Rapacz 8
,
Maciej Sroczyński 9
,
Mateusz Szmit 9
,
Stanisław Głuszek 10, 11, 12
  1. Collegium Medicum, Jan Kochanowski University, Kielce, Poland
  2. Independent Public Health Care Center of the Ministry of Internal and Administration, Gdańsk, Poland
  3. Department of General and Vascular Surgery, Faculty of Medicine, Medical University of Warsaw, Poland
  4. Department of Biomedicine – Unity of Anatomy, Faculdade de Medicina da Universidade do Porto, Portugal
  5. Department of Surgery – Unidade Local de Saúde do Médio Ave, Vila Nova de Famalicão, Portugal
  6. Siedlce University of Natural Sciences and Humanities, Poland
  7. Siedlce Hospital, Poland
  8. First Department of General Surgery, Jagiellonian University Medical College, Doctoral School of Medical and Health Sciences, Cracow, Poland
  9. Department of General, Minimally Invasive and Endocrine Surgery, Wroclaw Medical University, Poland
  10. Department of Surgical Oncology, Holy Cross Cancer Centre in Kielce, Poland
  11. Department of Surgery, Hospital of the Ministry of Interior and Administration in Kielce, Poland
  12. Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Magdalenka, Poland
Clin Exp HEPATOL 2025; 11, 2: 160-168
DOI: https://doi.org/10.5114/ceh.2025.151805
Online publish date: 2025/06/09
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Aim of the study:

Data concerning the clinical manifestation and outcomes of lean metabolic dysfunction-associated steatotic liver disease (MASLD) are scarce and inconsistent. The aim of the study was to evaluate the clinical characteristics of MASLD and predictors of its occurrence.

Material and methods:

The study included patients from the Polish Gallstone Surgery Registry diagnosed with MASLD according to the current criteria.

Results:

Among 3,419 patients, MASLD was diagnosed in 24.2%. Lean MASLD was diagnosed in 11.3% of patients with MASLD. Independent predictors of lean MASLD were atherogenic dyslipidaemia (OR = 94.16, CI: 45.54-197.71, p < 0.0001), diabetes mellitus or prediabetes conditions (OR = 9.26, CI: 4.42-19.38, p < 0.0001) and hypertension (OR = 2.97, CI: 1.38-6.41, p = 0.0054).

Conclusions:

Lean MASLD is not a rare form of the disease, and in the lean MASLD group there are patients with a high rate of metabolic abnormalities which may significantly increase cardiovascular risk and the risk of MASLD progression.

Keywords

obesity, overweight, liver steatosis

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