Simultaneous esophageal resection and pulmonary lobectomy for synchronous esophageal cancer and lung cancer is associated with an increased risk of postoperative complications, including esophageal leakage and broncho-pleural fistula [1]. Endoluminal vacuum therapy (EVT) has been reported to be effective in the treatment of anastomotic leak after esophageal resection [2]. However, in the event of a bronchial fistula, EVT may cause significant air leakage through the fistulas, which may eventually lead to respiratory complications and impede negative pressure treatment. Here we present a patient with bronchopleural and esophagopleural fistula successfully treated with surgery and EVT.