Connections between atherosclerosis and osteoarthritis – a literature review

Bartosz Pomianowski; Karolina Blady; Leon Smółka; Miłosz Strugała; Julia Pakulska; Krzysztof Osuch

doi:10.5114/.2025.151280

eISSN: 2084-9850
ISSN: 1897-3116

Pielęgniarstwo Chirurgiczne i Angiologiczne/Surgical and Vascular Nursing

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abstract:

Review paper

Connections between atherosclerosis and osteoarthritis – a literature review

Bartosz Pomianowski

^{1, 2}

,

Karolina Blady

²

,

Leon Smółka

²

,

Miłosz Strugała

²

,

Julia Pakulska

²

,

Krzysztof Osuch

³

Department of Orthopedics and Traumatology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland
Department of Anatomy, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland
Student Scientific Circle at the Third Department of Cardiology, Medical University of Silesia, Katowice, Poland

Pielęgniarstwo Chirurgiczne i Angiologiczne 2025; 19(1): 1-7

DOI: https://doi.org/10.5114/.2025.151280

Online publish date: 2025/05/22

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Osteoarthritis (OA) and atherosclerosis are chronic degenerative diseases with shared pathophysiological mechanisms. This review explores the link between atherosclerosis and OA progression, focusing on lipid metabolism and adipokines. A systematic review following PRISMA guidelines analyzed 57 studies from PubMed, Elsevier, NCBI, and Google Scholar (2005–2025). Obesity and metabolic disorders, including hypercholesterolemia, contribute significantly to both diseases. Shared mechanisms include chronic inflammation, adipokine dysregulation, and the presence of the Z39Ig protein in affected tissues. Statins, known for their pleiotropic effects, may lower cholesterol and provide chondroprotective benefits. Targeting metabolic factors may improve OA management. Further research on pathophysiological mechanisms and therapeutic interventions could enhance treatment strategies.

keywords:

Connections between atherosclerosis and osteoarthritis – a literature review

Bartosz Pomianowski 1, 2 , Karolina Blady 2 , Leon Smółka 2 , Miłosz Strugała 2 , Julia Pakulska 2 , Krzysztof Osuch 3

osteoarthritis, atherosclerosis, adipokines, lipid metabolism

Bartosz Pomianowski

^{1, 2}

,

Karolina Blady

²

,

Leon Smółka

²

,

Miłosz Strugała

²

,

Julia Pakulska

²

,

Krzysztof Osuch

³