Clinical and Experimental Hepatology
eISSN: 2449-8238
ISSN: 2392-1099
Clinical and Experimental Hepatology
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abstract:
Review paper

Current approach to diagnosis and treatment of focal nodular hyperplasia in children with a management algorithm

Anna Chudoba
1, 2
,
Joanna Pawłowska
2
,
Joanna Cielecka-Kuszyk
3
,
Dorota Majak
4, 5
,
Irena Jankowska
2
,
Dorota Broniszczak-Czyszek
6
,
Jakub Barański
4
,
Piotr Czubkowski
2

  1. Clinical Department of Pediatrics and Allergology, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland
  2. Department of Gastroenterology, Hepatology, Feeding Disorders, and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland
  3. Department od Pathology, Children’s Memorial Health Institute, Warsaw, Poland
  4. Department of Diagnostic Imaging, Children’s Memorial Health Institute, Warsaw, Poland
  5. Department of Pediatric Radiology, Medical University of Warsaw, Warsaw, Poland
  6. Department of Pediatric Surgery and Organ Transplantation, Children’s Memorial Health Institute, Warsaw, Poland
Clin Exp HEPATOL 2025; 11, 4
DOI: https://doi.org/10.5114/ceh.2025.155044
Online publish date: 2025/10/09
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Focal nodular hyperplasia (FNH) is a benign tumor of the liver rarely reported in children. It requires differentiation from malignant liver lesions, which are more common in the pediatric population. The pathogenesis of the disease remains unknown, but previous oncological treatment of non-liver neoplasms or vascular abnormalities may predispose to FNH development. Differential diagnosis is based on radiological imaging with rare indications for diagnostic biopsy or resection. There are no specific management guidelines for FNH in children, but in most cases watchful waiting is most appropriate. In symptomatic, rapidly growing cases, surgical or radiological intervention may be considered. In this review, we present the clinical features, natural course, and current management patterns in pediatric FNH.

Key words: children, diagnosis, management, FNH, focal nodular hyperplasia.
keywords:

children, diagnosis, management, FNH, focal nodular hyperplasia
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