Many of cytostatic drugs have mutagenic, teratogenic and carcinogenic properties, with no threshold dose for those effects. These properties make up a potential risk for healthcare workers who are occupationally exposed to those drugs during their preparation and management and taking care of patients undergoing the chemotherapy. Very limited literature data are available dealing with cancer risk in healthcare staff. In this article a critical overview of this literature is presented regarding carcinogenic potential of different cytostatic drugs and cancer risk level in various groups of the exposed staff.