Diagnosis of Hirschsprung’s disease with particular emphasis on histopathology.<br/> 
A systematic review of current literature

Łukasz Szylberg; Andrzej Marszałek

doi:10.5114/pg.2014.46160

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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5/2014
vol. 9

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Artykuł przeglądowy

Diagnosis of Hirschsprung’s disease with particular emphasis on histopathology.
A systematic review of current literature

Łukasz Szylberg

,

Andrzej Marszałek

Prz Gastroenterol 2014; 9 (5): 264–269

DOI: https://doi.org/10.5114/pg.2014.46160

Data publikacji online: 2014/10/18

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Metryki PlumX:

Hirschsprung’s disease (HD) is a disorder that involves several medical specialties such as paediatric gastroenterology, paediatric surgery, and pathology. Hirschsprung’s disease is a congenital bowel innervation disorder characterised by the absence of ganglion cells in myenteric (Auerbach) and submucosal (Meissner) plexus in the distal colon in its classical form. Rapid and accurate diagnosis of HD is a key element in further treatment patterns. The efficiency of different diagnostic methods used in HD patients may vary. Using one limited diagnostic procedure can lead to as much as a few per cent of overlooked cases. In recent years, rectal biopsy was recognised as an important diagnostic tool that allows for a definitive HD diagnosis with an accuracy of 95% of cases. A correct diagnosis depends on the localisation of the biopsied sample, its representativeness, the number of specimens, and proper interpretation of microscopic studies supported by histochemical and immunohistochemical methods. When several methods are used and all diagnostic criteria are used, the diagnostic sensitivity can almost eliminate cases of undiagnosed patients.

słowa kluczowe:

Diagnosis of Hirschsprung’s disease with particular emphasis on histopathology. A systematic review of current literature

Łukasz Szylberg , Andrzej Marszałek

Hirschsprung’s disease, diagnosis, histopathology

Diagnosis of Hirschsprung’s disease with particular emphasis on histopathology.
A systematic review of current literature

Łukasz Szylberg

,

Andrzej Marszałek