Kardiochirurgia i Torakochirurgia Polska

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2/2026 vol. 23
Original paper

Early clinical outcomes of routine prophylactic use of a gentamicin-impregnated sponge in all consecutive patients undergoing cardiac surgical operations: a single-center experience

Anna Witkowska 1
,
Kinga Koziarska 2
,
Jan Kaczmarek 2
,
Michał Rodzki 1
,
Marek Jemielity 1
,
Barłomiej Perek 1

  1. Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland

  2. University Clinical Hospital, Poznan, Poland

Kardiochirurgia i Torakochirurgia Polska 2026; 23 (2): 111-116

DOI: https://doi.org/10.5114/kitp.2026.163301
Data publikacji online: 2026/07/21
Article file
Early clinical.pdf
Confronting perimenopausal women’s knowledge of coronary heart disease with their health behaviours. Controversial role of hormone replacement therapy in the protection of coronary heart disease
  1. Young PY, Khadaroo RG. Surgical site infections. Surg Clin North Am 2014; 94: 1245-1264.
  2. Gelijns AC, Moskowitz AJ, Acker MA, Argenziano M, Geller NL, Puskas JD, Perrault LP, Smith PK, Kron IL, Michler RE, Miller MA, Gardner TJ, Ascheim DD, Ailawadi G, Lackner P, Goldsmith LA, Robichaud S, Miller RA, Rose EA, Fergu- son TB Jr, Horvath KA, Moquete EG, Parides MK, Bagiella E, O’Gara PT, Blackstone EH; Cardiothoracic Surgical Trials Network (CTSN). Management practices and major infections after cardiac surgery. J Am Coll Cardiol 2014; 64: 372-381.
  3. Zukowska A, Zukowski M. Surgical site infection in cardiac surgery. J Clin Med 2022; 11: 6991.
  4. Song Y, Chu W, Sun J, Liu X, Zhu H, Yu H, Shen C. Review on risk factors, classification, and treatment of sternal wound infection. J Cardiothorac Surg 2023; 18: 184.
  5. Perezgrovas-Olaria R, Audisio K, Cancelli G, Rahouma M, Ibrahim M, Soletti GJ, Chadow D, Demetres M, Girardi LN, Gaudino M. Deep sternal wound infection and mortality in cardiac surgery: a meta-analysis. Ann Thorac Surg 2023; 115: 272-280.
  6. Perrault LP, Kirkwood KA, Chang HL, Mullen JC, Gulack BC, Argenziano M, Gelijns AC, Ghanta RK, Whitson BA, Williams DL, Sledz-Joyce NM, Lima B, Greco G, Fumakia N, Rose EA, Puskas JD, Blackstone EH, Weisel RD, Bowdish ME. A prospective multi-institutional cohort study of mediastinal infections after cardiac operations. Ann Thorac Surg 2018; 105: 461-468.
  7. Mauermann WJ, Sampathkumar P, Thompson RL. Sternal wound infections. Best Pract Res Clin Anaesthesiol 2008; 22: 423-436.
  8. Yusuf E, Chan M, Renz N, Trampuz A. Current perspectives on diagnosis and management of sternal wound infections. Infect Drug Resist 2018; 11: 961-968.
  9. Ridderstolpe L, Gill H, Granfeldt H, Ahlfeldt H, Rutberg H. Superficial and deep sternal wound complications: incidence, risk factors and mortality. Eur J Cardiothorac Surg 2001; 20: 1168-1175.
  10. Sajja LR. Strategies to reduce deep sternal wound infection after bilateral internal mammary artery grafting. Int J Surg 2015; 16: 171-178.
  11. Vos RJ, Van Putte BP, Kloppenburg GTL. Prevention of deep sternal wound infection in cardiac surgery: a literature review. J Hosp Infect 2018; 100: 411-420.
  12. Kowalewski M, Ko³odziejczak MM, Urbanowicz T, De Piero ME, Mariani S, Pasierski M, Makhoul M, Comanici M, D¹browski EJ, Matteucci M, Massimi G, Litwinowicz R, Kowalówka A, Wañha W, Jiritano F, Martucci G, Raffa GM, Malvindi PG, Kuźma £, Suwalski P, Lorusso R, Meani P, Lazar H; Thoracic Research Centre. Regional antibiotic delivery for sternal wound infection prophylaxis a systematic review and meta-analysis of randomized controlled trials. Sci Rep 2024; 14: 9690.
  13. Aboul-Hassan SS, Stankowski T, Urbanowicz T, Luczak M, Luszczyn M, Moskal L, Nawotka M, Peksa M, Stanislawski R, Amelchanka S, Perek B, Jemieli- ty M, Matkowska DN, Brykczynski M, Bugajski P, Fritzsche D, Cichon R. Impact of topical vancomycin paste on prevention of deep sternal wound infection in patients undergoing bilateral internal thoracic artery coronary bypass grafting. Kardiochir Torakochir Pol 2026; 23: 24-30.
  14. Bennett-Guerrero E, Ferguson TB Jr, Lin M, Garg J, Mark DB, Scavo VA Jr, Kouchoukos N, Richardson JB Jr, Pridgen RL, Corey GR; SWIPE-1 Trial Group. Effect of an implantable gentamicin-collagen sponge on sternal wound infections following cardiac surgery: a randomized trial. JAMA 2010; 304: 755-762.
  15. Birgand G, Radu C, Alkhoder S, Al Attar N, Raffoul R, Dilly MP, Nataf P, Lu- cet JC. Does a gentamicin-impregnated collagen sponge reduce sternal wound infections in high-risk cardiac surgery patients? Interact Cardiovasc Thorac Surg 2013; 16: 134-141.
  16. Dyke C, Aronson S, Dietrich W, Hofmann A, Karkouti K, Levi M, Murphy GJ, Sellke FW, Shore-Lesserson L, von Heymann C, Ranucci M. Universal definition of perioperative bleeding in adult cardiac surgery. J Thorac Cardiovasc Surg 2014; 147: 1458-1463.
  17. Fuglestad MA, Tracey EL, Leinicke JA. Evidence-based prevention of surgical site infection. Surg Clin North Am 2021; 101: 951-966.
  18. de Tymowski C, Provenchère S, Para M, Duval X, Grall N, Sahnoun T, Iung B, Kernéis S, Lucet JC, Montravers P. Deep sternal wound infection after cardiac surgery: a combination of 2 distinct infection types, deep incisional surgical-site infection and mediastinitis: results of a retrospective study. Surgery 2025; 181: 109255.
  19. Kowalewski M, Pawliszak W, Zaborowska K, Navarese EP, Szwed KA, Kowalkowska ME, Kowalewski J, Borkowska A, Anisimowicz L. Gentamicin-collagen sponge reduces the risk of sternal wound infections after heart surgery: meta-analysis. J Thorac Cardiovasc Surg 2015; 149: 1631-1640.
  20. Magro PL, Sousa Uva M. Does routine topical antimicrobial administration prevent sternal wound infection after cardiac surgery? Interact Cardiovasc Thorac Surg 2021; 32: 452-456.
  21. Raja SG, Salhiyyah K, Rafiq MU, Felderhof J, Amrani M. Impact of gentamicin-collagen sponge (Collatamp) on the incidence of sternal wound infection in high-risk cardiac surgery patients: a propensity score analysis. Heart Surg Forum 2012; 15: E257-E261.
  22. Monaco C, Barone L, Cammalleri V, Stifano G, Magliano G, Geuna F, Romeo F, Sergi D. Local gentamicin-collagen sponge reduces cardiovascular implantable electronic device infections and pocket hematoma. Eur Rev Med Pharmacol Sci 2022; 26: 5218-5224.
  23. Stemberger A, Grimm H, Bader F, Rahn HD, Ascherl R. Local treatment of bone and soft tissue infections with the collagen-gentamicin sponge. Eur J Surg 1997; S578: 17-26.
  24. Moore H, Yeoh D, Hughes C, Raby E, Sandaradura I. Aminoglycosides: an update on indications, dosing and monitoring. Aust Prescr 2025; 48: 133-138.
  25. Sørensen TS, Sørensen AI. Bactericidal activity of gentamicin against S. aureus. In vitro study questions value of prolonged high concentrations. Acta Orthop Scand 1993; 64: 82-84.
  26. de Bruin AF, Gosselink MP, van der Harst E, Rutten HJ. Local application of gentamicin collagen implants in the prophylaxis of surgical site infections following gastrointestinal surgery: a review of clinical experience. Tech Coloproctol 2010; 14: 301-310.
  27. Bhawono Dadi T, Devriendt N, Cherlet M, Devreese M, Polis I, de Rooster H. Pharmacokinetic study of local and systemic gentamicin concentrations after subcutaneous implantation of a gentamicin-impregnated collagen sponge in dogs. Vet J 2024; 307: 106201.

Copyright: © 2026 Polish Society of Cardiothoracic Surgeons (Polskie Towarzystwo KardioTorakochirurgów) and the editors of the Polish Journal of Cardio-Thoracic Surgery (Kardiochirurgia i Torakochirurgia Polska). This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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