eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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vol. 5

Endometrial hyperplasia: efficacy of treatment with vaginal tablet containing natural micronized progesterone

Beata Szymańska
Agnieszka Gardyszewska
Joanna Pabich
Krzysztof Czajkowski

Prz Menopauz 2006; 2: 75–79
Online publish date: 2006/05/12
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The aim of this study was to evaluate the efficiency of treatment with a vaginal tablet containing natural micronized progesterone in patients with endometrial hyperplasia.
Material and methods:
Forty one patients with endometrial hyperplasia were enrolled in this trial; 38 patients have been presented simple hyperplasia, 3 complex hyperplasia. All patients were treated with vaginal tablets containing micronized progesterone 2 x 100 mg/day for 3 months. During first month of treatment 6 patients were bleeding and were excluded from the study. 35 patients finished treatment.
We observed a total of 33 complete regressions (94%). Recurrence of simple hyperplasia occurred in 1 patient (3%), and in 1 patient (3%) we noticed progresion from simple to complex hyperplasia. 7 patients (17%) had irregular spotting, 4 (9,8%) had vaginal discomfort.
Vaginal administration of natural micronized progesterone seems to be effective and safe therapy of benign endometrial hyperplasia, particularly indicated in women also affected by metabolic disorders.

progesterone, endometrial hyperplasia, vaginal administration

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