Abstract
4/2021
vol. 20
Review paper
Endometriosis and gynaecological cancers: molecular insights behind a complex machinery
- Department of Pathology, University of Louisville, Louisville, KY, United States
- Institute of Sexology, First Faculty of Medicine, Charles University, Prague, Czech Republic
- Department of Obstetrics and Gynocology, Azienda Ospedaliera Universitaria Integrata Verona, Italy
- Department of Women and Children's Health, University of Padua, Padua, Italy
- Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan
- Clinical Academic Department of Women's Health, National Research Center of Mother and Child Health, University Medical Center, Nur-Sultan, Kazakhstan
- Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States
- Department of Obstetrics and Gynecology, "Filippo Del Ponte" Hospital, University of Insubria, Varese, Italy
Menopause Rev 2021; 20(4): 201-206
Online publish date: 2021/12/06
Endometriosis is described as the presence of both endometrial glandular and stromal cells outside the uterine cavity. A major characterization of this disease is ectopic implantation of endometrial cells with increased migration. It is one of the leading causes of morbidity among premenopausal women, with a prevalence of 10–16% of women of reproductive age. Despite over century of intensive research, none of the current treatment options represents a real cure. Based on the current knowledge, endometriosis, particularly its atypical version, is considered to be a transitional form from benign disease to tumour. However, the exact mechanisms of this conversion are still not fully established.
Keywords
endometriosis, cancer, ovarian cancer
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