Endometriosis and gynaecological cancers: molecular insights behind a  complex machinery

Vaclav Vetvicka; Ludek Fiala; Simone Garzon; Giovanni Buzzaccarini; Milan Terzic; Antonio Simone Laganà

doi:10.5114/pm.2021.111276

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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4/2021
vol. 20

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abstract:

Review paper

Endometriosis and gynaecological cancers: molecular insights behind a complex machinery

Vaclav Vetvicka

¹

,

Ludek Fiala

²

,

Simone Garzon

³

,

Giovanni Buzzaccarini

⁴

,

Milan Terzic

^{5, 6, 7}

,

Antonio Simone Laganà

⁸

Department of Pathology, University of Louisville, Louisville, KY, United States
Institute of Sexology, First Faculty of Medicine, Charles University, Prague, Czech Republic
Department of Obstetrics and Gynocology, Azienda Ospedaliera Universitaria Integrata Verona, Italy
Department of Women and Children's Health, University of Padua, Padua, Italy
Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan
Clinical Academic Department of Women's Health, National Research Center of Mother and Child Health, University Medical Center, Nur-Sultan, Kazakhstan
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States
Department of Obstetrics and Gynecology, "Filippo Del Ponte" Hospital, University of Insubria, Varese, Italy

Menopause Rev 2021; 20(4): 201-206

DOI: https://doi.org/10.5114/pm.2021.111276

Online publish date: 2021/12/06

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Endometriosis is described as the presence of both endometrial glandular and stromal cells outside the uterine cavity. A major characterization of this disease is ectopic implantation of endometrial cells with increased migration. It is one of the leading causes of morbidity among premenopausal women, with a prevalence of 10–16% of women of reproductive age. Despite over century of intensive research, none of the current treatment options represents a real cure. Based on the current knowledge, endometriosis, particularly its atypical version, is considered to be a transitional form from benign disease to tumour. However, the exact mechanisms of this conversion are still not fully established.

keywords:

Endometriosis and gynaecological cancers: molecular insights behind a complex machinery

Vaclav Vetvicka 1 , Ludek Fiala 2 , Simone Garzon 3 , Giovanni Buzzaccarini 4 , Milan Terzic 5, 6, 7 , Antonio Simone Laganà 8

endometriosis, cancer, ovarian cancer

Vaclav Vetvicka

¹

,

Ludek Fiala

²

,

Simone Garzon

³

,

Giovanni Buzzaccarini

⁴

,

Milan Terzic

^{5, 6, 7}

,

Antonio Simone Laganà

⁸