Clinical and Experimental Hepatology

Abstract

3/2021 vol. 7
Original paper

Evaluation of interleukin 8 polymorphisms (-251T/A and +781C/T) in patients with hepatocellular carcinoma: a meta-analysis

Omid Emami Aleagha 1, 2
,
Forouzan Moeinzadeh 3
,
Seyedeh Farnaz Moeini Shokouh 3
,
Erkan Doğan 4
,
Masoud Sadeghi 5
  1. Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. Department of Medicine, Najafabad Branch, Islamic Azad University, Najafabad, Iran
  4. Department of Pediatrics, Karabuk University, Faculty of Medicine, Karabuk, Turkey
  5. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Clin Exp HEPATOL 2021; 7, 3: 278-285
DOI: https://doi.org/10.5114/ceh.2021.109424
Online publish date: 2021/10/12
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Introduction

We reported the association between interleukin 8 (IL-8) polymorphisms (-251T/A and +781C/T) and hepatocellular carcinoma (HCC) risk in a meta-analysis.

Material and methods

Scopus, PubMed, Web of Science, and Cochrane Library databases were searched until 21 November 2020. The analyses were performed by RevMan 5.3 software using odds ratios (ORs) and 95% confidence intervals (CIs). Also, the analysis of publication bias was performed by CMA 2.0 software.

Results

Searching databases/sources, five articles including ten studies were entered into the meta-analysis. The pooled ORs for -251T/A polymorphism were 1.07 (p = 0.55), 1.04 (p = 0.75), 1.31 (p = 0.24), 1.24 (p = 0.31), and 1.85 (p = 0.29) for allele, homozygote, heterozygote, recessive and dominant models, respectively. With regards to +781C/T polymorphism, the pooled ORs were 0.74 (p = 0.07), 0.53 (p = 0.03), 0.83 (p = 0.41), 0.75 (p = 0.19), and 0.57 (p = 0.02) for allele, homozygote, heterozygote, recessive, and dominant models, respectively.

Conclusions

The findings of the meta-analysis showed a lack of significant association between IL-8 (-251T/A) polymorphism and the HCC risk, whereas the TT genotype of IL-8 (+781C/T) polymorphism had a protective role in HCC.

Keywords

hepatocellular carcinoma, interleukin 8, liver cancer, polymorphism

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