eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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SCImago Journal & Country Rank
10/2002
vol. 6
 
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abstract:

Genetically modified dendritic cells as a cancer treatment strategy

Andrzej Mackiewicz
,
Dariusz W. Kowalczyk
,
Małgorzata Mackiewicz-Wysocka
,
Piotr Grabarczyk
,
Piotr J. Wysocki

Współcz Onkol (2002), vol. 6, 10, 637-642
Online publish date: 2003/03/26
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Dendritic cells (DCs), the most potent APCs have been discovered almost 30 years ago. Due to priming of antigen-specific immune responses mediated by CD4+ and CD8+ lymphocytes, DCs are crucial for the induction of adaptive immunity against cancer. Therefore, vaccination of cancer patients with DCs presenting tumor associated antigens (TAAs) have been believed to be a promising anti-cancer strategy. Until now multiple clinical trials have been carried out in order to evaluate the safety and efficacy of cancer vaccines based on antigen-pulsed DCs. However, pulsing of DCs with particular peptides has several disadvantages: (i) short-time duration of antigen-MHC complexes, (ii) requirement for matching of defined peptides with MHC complexes and (iii) exclusive presentation of single antigen epitopes.
Application of gene transfer technologies in the field of DCs-based vaccines made possible the development of novel, anti-cancer immunization strategies. In several animal models, DCs modified with genes encoding TAA or immunostimulatory proteins have been shown to be effective in induction of anti-tumor immune responses. Based on these encouraging results, a first clinical trial of vaccination of prostate cancer patients with gene modified DCs has been recently initiated.
keywords:

dendritic cell, genetic modification, cancer vaccine, cytokine, TAAs

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