Glioblastoma with an uncommon TP53 mutation presenting with pleural metastasis: a case report and literature review

Zuzanna Biegała; Oliwia Kowalczyk; Julia Sołek; Piotr Czapiewski; Jakub Jankowski; Maciej Radek; Dominik Paprocki; Witold Skierkowski; Marcin Braun

doi:10.5114/wo.2025.158129

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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abstract:

Case report

Glioblastoma with an uncommon TP53 mutation presenting with pleural metastasis: a case report and literature review

Zuzanna Biegała

¹

,

Oliwia Kowalczyk

¹

,

Julia Sołek

¹

,

Piotr Czapiewski

^{2, 3}

,

Jakub Jankowski

⁴

,

Maciej Radek

⁴

,

Dominik Paprocki

¹

,

Witold Skierkowski

¹

,

Marcin Braun

¹

Department of Pathology, Chair of Oncology, Medical University of Lodz, Lodz, Poland
Department of Pathology, Staedtisches/Städtisches Klinikum Dessau, Brandenburg Medical School Theodor Fontane, Dessau, Germany
Department of Pathology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
Clinic of Neurosurgery, Spine Surgery and Peripheral Nerve Surgery, Medical University of Lodz, Lodz, Poland

Contemp Oncol (Pozn) 2025; 30 (1)

DOI: https://doi.org/10.5114/wo.2025.158129

Online publish date: 2026/02/23

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Extracranial metastasis of glioblastoma (GBM) is an extremely rare phenomenon and is associated with a poor prognosis. Here, we present the case of a 55-year-old woman who developed pleural metastasis of GBM, manifesting non-specific breathing difficulties during treatment. This case highlights the importance of integrating multiple diagnostic approaches, as only the comparison of histopathological examination results with the patient’s clinical history – right temporal lobe GBM – enabled the final diagnosis of GBM metastasis. Next-generation sequencing was performed as part of the diagnostic workup and revealed a p.G266R TP53 mutation. Additionally, imaging revealed an extensive heterogeneous lesion at the site of the previously resected GBM, which proved to be an inoperable gliosarcoma (World Health Organization grade 4). This rare presentation of GBM with distant pleural metastasis, combined with the identification of an uncommon TP53 mutation, represents a unique diagnostic and clinical challenge and underscores the novelty of this case.

keywords:

Glioblastoma with an uncommon TP53 mutation presenting with pleural metastasis: a case report and literature review

Zuzanna Biegała 1 , Oliwia Kowalczyk 1 , Julia Sołek 1 , Piotr Czapiewski 2, 3 , Jakub Jankowski 4 , Maciej Radek 4 , Dominik Paprocki 1 , Witold Skierkowski 1 , Marcin Braun 1

glioblastoma, metastasis, pleura, TP53 mutation, progression, gliosarcoma

Zuzanna Biegała

¹

,

Oliwia Kowalczyk

¹

,

Julia Sołek

¹

,

Piotr Czapiewski

^{2, 3}

,

Jakub Jankowski

⁴

,

Maciej Radek

⁴

,

Dominik Paprocki

¹

,

Witold Skierkowski

¹

,

Marcin Braun

¹