eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
1/2019
vol. 23
 
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abstract:
Case report

Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation

Yöntem Yaman
,
Gökhan Baysoy
,
Emre Keleşoğlu
,
Kürşat Özdilli
,
Aslı Çakır
,
Dildar Bahar Genç
,
Murat Elli
,
Sema Anak

Contemp Oncol (Pozn) 2019; 23 (1): 59-62
Online publish date: 2019/03/25
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In the pediatric population, hematopoietic stem cell transplantation (HSCT) is used to treat a wide variety of diseases, both malignant and nonmalignant. For many of these diseases, HSCT is a well-established treatment. Acute graft-versus-host disease (GVHD) continues to be a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Graft versus host disease is a common complication of allo-SCT which is induced by donor T cell recognition of recipient alloantigens. The occurrence of autologous GVHD suggests that inappropriate recognition of host self-antigens may occur. GVHD in patients who received autologous HSCT is extremely rare compared to patients who received allogeneic HSCT. We present the case of a 4-year-old girl with metastatic neuroblastoma who spontaneously developed autologous GVHD after autologous HSCT.
keywords:

graft-versus-host disease, child, neuroblastoma, autologous stem cell transplantation

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