eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
4/2021
vol. 17
 
Share:
Share:
more
 
 
abstract:
Original paper

Higher levels of TWEAK and matrix metalloproteinase-3 during the acute phase of myocardial infarction are associated with adverse left ventricular remodeling

Ferhat Eyyupkoca
1
,
Cengiz Sabanoglu
2
,
Mehmet Sait Altintas
3
,
Ajar Kocak
1
,
Karabekir Ercan
4
,
Nilnur Eyerci
5
,
Sercan Okutucu
6

1.
Department of Cardiology, Dr. Nafiz Korez Sincan State Hospital, Ankara, Turkey
2.
Department of Cardiology, Kirikkale High Specialization Hospital, Kirikkale, Turkey
3.
Department of Cardiology, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey
4.
Department of Radiology, Ankara Bilkent City Hospital, Ankara, Turkey
5.
Deparment of Medical Biology, Kafkas University Faculty of Medicine, Kars, Turkey
6.
Department of Cardiology, Memorial Ankara Hospital, Ankara, Turkey
Adv Interv Cardiol 2021; 17, 4 (66): 356–365
Online publish date: 2021/12/28
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction
It is known that the levels of tumor necrosis factor-like weak inducer of apoptosis (TWEAK/TNFSF12) increase after myocardial infarction (MI) and that it interacts with sCD163. It has also been argued that TWEAK can induce matrix metalloproteinases (MMPs) in macrophages.

Aim: To investigate the roles of TWEAK, sCD163, and MMPs in left ventricular (LV) adverse remodeling (AR) in the early post-MI period.

Material and methods
Forty-six patients with ST-elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention were enrolled in the study. Post-MI LV functions and volumes were assessed by cardiac magnetic resonance imaging at 2 weeks and 6 months. Cytokines and MMPs were measured using a bead-based multiplex immunoassay system at 1 day (baseline) and 2 weeks post-MI. AR was defined as an increase in LV end-diastolic volume of ≥ 10% at the 6-month follow up.

Results
The TWEAK, MMP-2, and MMP-3 baseline levels were higher in the patients with AR than those without AR. At 2 weeks post-MI, these expression levels were similar in patients with and without AR, but sCD163 expression was increased in patients without AR. The TWEAK and MMP levels were positively correlated in the early period post-MI. At first day post-MI, higher levels of TWEAK and MMP-3 were predictors of AR (OR = 1.03, p = 0.006; OR = 1.08, p = 0.015; respectively).

Conclusions
TWEAK can induce MMPs in the early period post-MI, and these higher levels contribute to development of AR. Increased sCD163 levels at 2 weeks post-MI seem to be associated with the healing process through neutralizing the excessive inflammatory effects of TWEAK.

keywords:

inflammation, matrix metalloproteinase, cardiac remodeling, TWEAK, soluble CD163

Quick links
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.