Hutchinson-Gilford progeria syndrome: a rare premature ageing syndrome

Iti Varshney; Mohammad Adil; Syed Suhail Amin; Mohd Mohtashim; Annu Priya; Mahtab Alam

doi:10.5114/dr.2020.96361

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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2/2020
vol. 107

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abstract:

Case report

Hutchinson-Gilford progeria syndrome: a rare premature ageing syndrome

Iti Varshney

¹

,

Mohammad Adil

¹

,

Syed Suhail Amin

¹

,

Mohd Mohtashim

¹

,

Annu Priya

¹

,

Mahtab Alam

¹

Department of Dermatology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India

Dermatol Rev/Przegl Dermatol 2020, 107, 179–183

DOI: https://doi.org/10.5114/dr.2020.96361

Online publish date: 2020/06/25

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Hutchinson-Gilford progeria syndrome is an extremely rare genetic disorder characterized by premature ageing involving the skin, bones, heart, and blood vessels. The incidence is 1 in several million births. It occurs sporadically and is probably an autosomal dominant syndrome. The diagnosis is essentially clinical and the manifestations become more evident from the first year of life. We report a case of a seven-month- old boy with clinical manifestations characteristic of this syndrome. He had a characteristic “plucked-bird” appearance, prominent eyes and scalp veins, senile look, loss of scalp hair, stunted growth and mottled pigmentation with sclerodermatous changes over the trunk and lower limbs. This interesting case is reported for its rarity.

keywords:

Hutchinson-Gilford progeria syndrome: a rare premature ageing syndrome

Iti Varshney 1 , Mohammad Adil 1 , Syed Suhail Amin 1 , Mohd Mohtashim 1 , Annu Priya 1 , Mahtab Alam 1

premature ageing syndrome, progeria, ageing

Iti Varshney

¹

,

Mohammad Adil

¹

,

Syed Suhail Amin

¹

,

Mohd Mohtashim

¹

,

Annu Priya

¹

,

Mahtab Alam

¹