eISSN: 2299-551X
ISSN: 0011-4553
Journal of Stomatology
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2/2021
vol. 74
 
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abstract:
Original paper

Hyaluronic acid 0.2% application enhanced periodontitis treatment in non-surgical phase

Thuy T. Nguyen
1
,
Hoa T. Ho
1
,
Nam C. Huynh
2
,
Vu H.A. Dien
3
,
Thuy L. Vo
4

1.
Department of Periodontology, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
2.
Department of Dental Basic Sciences, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
3.
Department of Dental Public Health, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
4.
Department of Implantology, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
J Stoma 2021; 74, 2: 76-83
Online publish date: 2021/06/14
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Introduction
Topical hyaluronic acid (HA) has been considered as an adjuvant agent for periodontitis (PD). Objectives: This study aimed to assess the clinical effects of subgingival application of 0.2% HA gel, following scaling and root planning (SRP) in PD patients.

Material and methods
In this randomized split-mouth study, 733 periodontal pockets of 28 patients with PD were investigated. They were divided into control and experimental groups. The experimental group received subgingival administration of 1 ml 0.2% HA gel into each pocket immediately after SRP, and then after 1 week, 2 weeks, and 3 weeks. Clinical parameters and subgingival plaque were assessed at baseline and 6 weeks after SRP. Quantitative real-time polymerase chain reaction for Porphyromonas gingivalis (Pg), Treponema denticola (Td), Fusobacterium nucleatum (Fn), and Tannerella forsythia (Tf) were also performed.

Results
After 6 weeks, there were significant decreases in clinical parameters, and the number of Fn in the expe­rimental group compared to the control group (p < 0.05). The number of Pg, Td, and Tf decreased significantly in both groups, with no significant difference between the 2 cohorts (p > 0.05).

Conclusions
he topical application of HA gel in periodontal pockets after SRP may have a beneficial effect in PD patients. This additional treatment appears to help reducing 2 types of bacteria (Tf and Fn) better than non-surgical treatment only.

keywords:

chronic periodontitis, adjunctive therapy, hyaluronic acid, bactericidal efficiency, clinical parame­ters

 
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