eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
7/2008
vol. 12
 
Share:
Share:
more
 
 
abstract:

Immunotherapy of renal cell cancer – new targets and new strategies

Piotr J. Wysocki, Jakub Żołnierek

Współczesna Onkologia (2008) vol. 12; 7 (295–300)
Online publish date: 2008/11/03
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Various immunotherapeutic approaches for the treatment of renal cell carcinoma (RCC) have been developed for >90 years. However, the majority of them were clinically ineffective. Objective clinical effects have been seen only in the case of systemic administration of recom-binant cytokines – IFN-alpha and IL-2. With the advent of molecularly targeted biological therapies, which turned out to be significantly effective in the treatment of metastatic RCC, to many oncologists immunotherapy may seem to be moving into the periphery of RCC treatment strategies. However, various novel, sophisticated immunotherapeutic appro-aches for the treatment of RCC are still being developed. The development of active and passive specific immu-notherapeutic approaches, along with the possibility to \'switch off\' particular immunosuppressive mecha-nisms (e.g. elimination of regulatory T cells, blockage of cytotoxic T lymphocyte antigen-4 signalling), have paved the way for future trials of new immunotherapies of RCC. However, the new studies will have to enrol optimally selected patients (nephrectomized, with non-massive metastases and good performance status) and will use tumour response criteria that are specifically optimized for clinical trials of immunotherapy.
keywords:

immunotherapy, renal cell cancer, cytokine, vaccine, antibody

Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe