Influence of psychoactive substances on the immune system and involvement of the brain through immunologically-mediated mechanisms

Hamidreza Famitafreshi; Morteza Karimian

doi:10.5114/ain.2021.113514

eISSN: 1689-3530
ISSN: 0867-4361

Alcoholism and Drug Addiction/Alkoholizm i Narkomania

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4/2021
vol. 34

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abstract:

Review paper

Influence of psychoactive substances on the immune system and involvement of the brain through immunologically-mediated mechanisms

Hamidreza Famitafreshi

¹

,

Morteza Karimian

²

Department of Physiology, Tehran University of Medical Sciences – International Campus, Tehran, Iran

Department of Physiology, Tehran University of Medical Sciences, Tehran, Iran

Alcohol Drug Addict 2021; 34 (4): 299-306

DOI: https://doi.org/10.5114/ain.2021.113514

Online publish date: 2022/02/11

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Dependence continues to be an unsolvable problem. Now, some people become dependent or abuse psychoactive substances as a recreational activity. Many think they can give up any time but many progress to dependence. Although the brain is an immune-privileged organ recent studies suggest neuroinflammation can alter brain function. The focus of this review article is discussing a different aspect of the immune system in drug dependence. Also, the adverse effect of substance abuse on the immune system and the possible outcome is investigated.

keywords:

Influence of psychoactive substances on the immune system and involvement of the brain through immunologically-mediated mechanisms

Hamidreza Famitafreshi 1 , Morteza Karimian 2

Reward center, Toll-like receptors, Withdrawal syndrome, Cytokine and cell-mediated immune system, Hormonal immune system

Hamidreza Famitafreshi

¹

,

Morteza Karimian

²