Intense pustular reaction during treatment of actinic keratosis with ingenol mebutate

Dorota Jaśkiewicz-Nyckowska; Zuzanna Lewicka-Potocka; Aneta Szczerkowska-Dobosz

doi:10.5114/dr.2015.51927

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

3/2015
vol. 102

Send email

Copy url:

abstract:

Intense pustular reaction during treatment of actinic keratosis with ingenol mebutate

Dorota Jaśkiewicz-Nyckowska

,

Zuzanna Lewicka-Potocka

,

Aneta Szczerkowska-Dobosz

Przegl Dermatol 2015, 102, 244–247

DOI: https://doi.org/10.5114/dr.2015.51927

Online publish date: 2015/06/15

View full text Get citation

PlumX metrics:

Introduction. Actinic keratosis is a common diagnosis in dermatological practice. Lesions usually appear on senile skin or skin exposed to sunlight. As they can progress to squamous cell carcinoma, all lesions should be properly treated. Ingenol mebutate is one of the newest topical agents.

Objective. To present a severe site reaction during treatment of actinic keratosis with ingenol mebutate gel.

Case report. An 85-year-old patient was treated with ingenol mebutate for an actinic keratosis lesion on the head. After the third day of treatment a massive local reaction was observed, with numerous pustular lesions. It was treated with a topical antibacterial agent. Complete remission of actinic keratosis was observed one month later.

Conclusions. Treatment of actinic keratosis with ingenol mebutate carries the risk of local adverse effects, including severe pustular reaction. Patients should always be informed about possible side effects of the treatment and their transient nature.

keywords:

Intense pustular reaction during treatment of actinic keratosis with ingenol mebutate

Dorota Jaśkiewicz-Nyckowska , Zuzanna Lewicka-Potocka , Aneta Szczerkowska-Dobosz

drug reactions, actinic keratosis, ingenol mebutate

Dorota Jaśkiewicz-Nyckowska

,

Zuzanna Lewicka-Potocka

,

Aneta Szczerkowska-Dobosz