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eISSN: 2084-9893
ISSN: 0033-2526
Dermatology Review/Przegląd Dermatologiczny
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SCImago Journal & Country Rank
6/2016
vol. 103
 
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abstract:
Review paper

Low frequency of skin cancers in vitiligo patients

Barbara Algiert
,
Anna Erkiert-Polguj
,
Agnieszka Dana
,
Dariusz Czubiński
,
Helena Rotsztejn

Przegl Dermatol 2016, 103, 486–490
Online publish date: 2016/12/05
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Vitiligo is a disease characterized by discoloration of the skin and hair as a result of damage of melanocytes. The exact mechanism of the disease is still unknown. Theories about the pathogenesis focus on autoimmune, neurogenic and autocytotoxic mechanisms. There is a decreased risk of incidence of skin cancers in patients with vitiligo. The relation between vitiligo and decreased frequency of cases of malignant melanoma (MM) may be a consequence of the immune response to antigens, which are common for melanocytes and MM cells. Genetic studies indicate a mutually exclusive relationship of melanoma and vitiligo. This disease is also associated with a polymorphism in the TYR gene which encodes tyrosinase. Studies also indicate a decreased risk of incidence of nonmelanoma skin cancers (NMSC) in patients with vitiligo.
keywords:

vitiligo, malignant melanoma, nonmelanoma skin cancers



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