Abstract
Lower fluorodeoxyglucose positron emission tomography maximum standardized uptake value may show a better response to stereotactic body radiotherapy of adrenals in oligometastatic disease
- Department of Radiotherapy, MHAT “Heart and Brain”, Pleven, Bulgaria
- Department of Nuclear Medicine, SHAT in Oncology, Sofia, Bulgaria
- University Hospital St. Marina, Varna, Bulgaria
- Department of Radiotherapy, MHAT “City Clinic”, Sofia, Bulgaria
- Department of Radiotherapy, SHAT in Oncology, Sofia, Bulgaria
- Clinic of Medical Oncology, MHAT “Nadezhda”, Sofia, Bulgaria
- Department of Radiotherapy, Uni Hospital, Panagyurishte, Bulgaria
Introduction:
Stereotactic body radiotherapy (SBRT) is well established for oligometastatic disease, and it is increasingly used to treat adrenal metastases.
Material and methods:
In this retrospective study we performed an analysis of 75 metastatic adrenal lesions in 64 patients with oligometastatic disease. According to the fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) maximum standardized uptake value (SUVmax) of adrenal metastases, patients were categorized into three groups: low, intermediate, and high SUVmax.
Results:
For all clinicopathological characteristics we found significant relationships for levels of SUVmax and objective response rate (Kendall Tau-c = 0.290; p = 0.017). Patients who responded to SBRT had a significantly lower SUVmax value than those who did not respond (7.6 ±2.4 vs. 9.7 ±3.8; p = 0.015). At the appropriate SUVmax cut-off values, the biomarker distinguished between patients with and without a response significantly and moderately (area under the curve = 0.670, 95% confidence intervals: 0.540–0.790; p = 0.015).
Conclusions:
Lower SUVmax is associated with a better response to SBRT in patients whose disease progressed mainly in the adrenal glands.
Keywords
adrenal gland, positron emission tomography, stereotactic radiotherapy, oligometastatic disease
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