Abstract
5/2017
vol. 70
Macrophage in periodontal inflammation
- Department of Pathology, Medical Institute of Sumy State University
- Department of Pathological Anatomy, Sumy State University
- Department of Therapeutic Dentistry, Kiev University UANM
Online publish date: 2017/01/07
Aim of the study. To investigate the expression of CD68
and HSP90AA1 in periodontal inflammation. Methods.
A total of twenty-seven patients (giant-cell epulis) and
thirty patients (acute and chronic inflammations) have
been examined for expression of CD68 and HSP90AA1
by hematoxylin – eosin and immunohistochemistry.
Results. Strong giant-cell positivity for CD68 was
observed in 100% of patients whereas only 85.31% of
giant-cell was positive for HSP90AA1 (p<0.05). Strong
macrophage immunoreactivity for CD68 was figured in
acute 23.2±1.3%, and in chronic 83.1±5.6% (p<0.05)
inflammation. Immunoreactivity for HSP90AA1 was
fixed in acute and chronic inflammation 98.2±1.79%.
Conclusion. Inflammatory macrophages are a group
of cells with protective functions, macrophages being
more set up in chronic inflammation. Central giant
cell epulis is the multinucleated macrophages, formed
as a result of chronic inflammation. Population of
macrophages resulted in bone resorption.
and HSP90AA1 in periodontal inflammation. Methods.
A total of twenty-seven patients (giant-cell epulis) and
thirty patients (acute and chronic inflammations) have
been examined for expression of CD68 and HSP90AA1
by hematoxylin – eosin and immunohistochemistry.
Results. Strong giant-cell positivity for CD68 was
observed in 100% of patients whereas only 85.31% of
giant-cell was positive for HSP90AA1 (p<0.05). Strong
macrophage immunoreactivity for CD68 was figured in
acute 23.2±1.3%, and in chronic 83.1±5.6% (p<0.05)
inflammation. Immunoreactivity for HSP90AA1 was
fixed in acute and chronic inflammation 98.2±1.79%.
Conclusion. Inflammatory macrophages are a group
of cells with protective functions, macrophages being
more set up in chronic inflammation. Central giant
cell epulis is the multinucleated macrophages, formed
as a result of chronic inflammation. Population of
macrophages resulted in bone resorption.
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