Journal of Stomatology

Abstract

6/2017 vol. 70

Macrophage in periodontal inflammation

Yevhen Kuzenko 1
,
Anatoly Romanyuk Romanyuk 2
,
Antonina Politun 3
  1. Medical Institute of Sumy State University, Department of Pathology
  2. Sumy State University, Department of Pathological Anatomy
  3. Department of Therapeutic Dentistry, Kiev University UANM,
DOI: https://doi.org/10.5604/00114553.1230588
Online publish date: 2017/01/07
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Confronting perimenopausal women’s knowledge of coronary heart disease with their health behaviours. Controversial role of hormone replacement therapy in the protection of coronary heart disease
Aim of the study. To investigate the expression of CD68
and HSP90AA1 in periodontal inflammation. Methods.
A total of twenty-seven patients (giant-cell epulis) and
thirty patients (acute and chronic inflammations) have
been examined for expression of CD68 and HSP90AA1
by hematoxylin – eosin and immunohistochemistry.
Results. Strong giant-cell positivity for CD68 was
observed in 100% of patients whereas only 85.31% of
giant-cell was positive for HSP90AA1 (p<0.05). Strong
macrophage immunoreactivity for CD68 was figured in
acute 23.2±1.3%, and in chronic 83.1±5.6% (p<0.05)
inflammation. Immunoreactivity for HSP90AA1 was
fixed in acute and chronic inflammation 98.2±1.79%.
Conclusion. Inflammatory macrophages are a group
of cells with protective functions, macrophages being
more set up in chronic inflammation. Central giant
cell epulis is the multinucleated macrophages, formed
as a result of chronic inflammation. Population of
macrophages resulted in bone resorption

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