eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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2/2000
vol. 4
 
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abstract:

Neoadjuvant radiochemotherapy in squamous cell cancer of the esophagus – morphological assessment and clinical results

Andrzej Bernacki
,
Jacek Nikliński
,
Jerzy Laudański
,
Krzysztof Furman
,
Marian Furman
,
Mirosław Kozłowski
,
Stanisław Kiluk

Współcz Onkol (2000) vol. 4, 2 (58-60)
Online publish date: 2003/07/25
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The study was perfomed in 37 pateints with squamous cell carcinoma of the esophagus in two groups. In group I – 12 patients received no preoperative treatment, in group II – in 25 patients preoperative concurrent radiotherapy (200 cGy/day to tatal dose of 3000 cGy) and chemotherapy (Cisplatin – on days 1 to 5 and 17 to 21 at a dose of 20 mg/m2/day and 5-Fluorouracyl continuous i. v. infusion of 300 mg/m2/day) were administered. In group II after operation in 4 patients microscopic examination revealed no presence of cancer cells – complete response (CR). Of twelve patients with reduction of neoplastic infiltration 7 had partial response 1 (PR1) and 5 had partial response 2 (PR2). In 7 patients no changes were detected – stable disease (SD). In clinical examination we assessed – stage of the disease (pTNM), postoperative complications and 2-years survival. 27% of the patients in group I and 48% of patients in group II survived 2 years after the operation.

Conclusions: Neoadjuvant radiochemotherapy improves 2-years survival rate in squamous cell esophageal cancer. Long term clinical results correlate with the response of the tumour to the preoperative treatment.
keywords:

esophageal cancer, neoadjuvant radiochemotherapy

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