eISSN: 2081-2833
ISSN: 2081-0016
Medycyna Paliatywna/Palliative Medicine
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
3/2013
vol. 5
 
Share:
Share:
abstract:
Review paper

Opioid-induced hyperalgesia a practical problem in the treatment of pain in patients with a cancer

Michał Walter Magiera
,
Leszek Strzelecki

Medycyna Paliatywna 2013; 5(3): 88–92
Online publish date: 2013/11/08
View full text Get citation
 
A complication of the opioid-based treatment of pain in patients with a cancer could be opioid-induced hyperalgesia. This phenomenon is paradoxical occurrence of pain or exacerbation of pain during the use of opioid analgetics. Opioid-induced hyperalgesia is associated with changes in the conformation of the opioid receptors. In this paper based on the literature presens 6 mechanisms of this phenomenon. These are: stimulation of NMDA receptors, opioid receptors desensitization, the effect of dynorphin A, descending impulse control pain associated with activation of On-Off cells, increasing the level of cAMP and genetic changes involving the substitution of methionine by valine affecting neurotransmission of dopamine/norepinephrine. In the following section describes the proposed method of treatment of opioid-induced hyperalgesia.
keywords:

opioid-induced hyperalgesia, cancer-releated pain

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.