Clinical and Experimental Hepatology
eISSN: 2449-8238
ISSN: 2392-1099
Clinical and Experimental Hepatology
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3/2025
vol. 11
 
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abstract:
Original paper

Oral health-related quality of life and oral function in patients with metabolic dysfunction associated steatotic liver disease

Kouichi Miura
1
,
Naoshi Arai
1
,
Miki Ishikawa
2
,
Takako Yasuda
2
,
Nobue Wakabayashi
1
,
Aki Yamamoto
1
,
Yoshiyuki Mori
3
,
Kyoko Nakao
1
,
Hironori Yamamoto
1
,
Kazuhiko Kotani
1

  1. Jichi Medical University, Japan
  2. Sanstar Inc., Japan
  3. Jichi Medical University Saitama Medical Center, Japan
Clin Exp HEPATOL 2025; 11, 3: 232–241
DOI: https://doi.org/10.5114/ceh.2025.154497
Online publish date: 2025/09/30
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Aim
Patients with metabolic dysfunction associated steatotic liver disease (MASLD) frequently experience periodontal diseases, but little is known about oral health-related quality of life (OHRQoL). Additionally, oral functions and the association between oral functions and MASLD remain unknown.

Material and methods
The study included 19 MASLD patients and 26 control subjects. OHRQoL was assessed using the General Oral Health Assessment Index (GOHAI). Additionally, oral hygiene, periodontal conditions, and oral functions, including numbers of functional and dysfunctional teeth, were examined.

Results
All MASLD patients were in the early stage of liver fibrosis and reported lower OHRQoL, particularly in physical components, including biting and chewing, and fluent speech. However, objective examinations revealed no significant differences in chewing and tongue pressure between MASLD and control subjects. Oral diadochokinesis also showed no significant difference. In contrast, MASLD patients exhibited fewer functional teeth, poorer oral hygiene, and more deteriorated periodontal condition. A reduced number of teeth was associated with MASLD, independent of periodontitis.

Conclusions
MASLD patients reported lower OHRQoL and perceived impaired oral functions before actual functional loss occurred. A decreased number of functional teeth was associated with the presence of MASLD.

keywords:

MASLD, oral health-related quality of life, oral function, number of teeth
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