eISSN: 2084-9885
ISSN: 1896-6764
Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
3/2012
vol. 7
 
Share:
Share:
more
 
 
abstract:

Original article
Evaluation of lymphocyte subsets and cytokine concentration in patients with schizophrenia

Paweł Wójciak
,
Agnieszka Remlinger-Molenda
,
Małgorzata Sobieska
,
Artur Kostrzewa
,
Janusz Rybakowski

Neuropsychiatria i Neuropsychologia 2012; 7, 3: 122–129
Online publish date: 2012/11/20
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction: Schizophrenia is associated with immune system dysfunction. These dysfunctions are reflected, among others, in changes of lymphocyte subsets and cytokine levels.

Aim of the study: To evaluate lymphocyte subsets and cytokine concentration in patients with schizophrenia.

Material and methods: Lymphocyte subsets evaluation (CD3+, CD4+, CD8+, CD16+, CD19+, CD4/CD8) was performed in 28 patients with schizophrenia (12 men and 16 women aged from 19 to 56 years) using the flow cytometry method. The cytokine evaluation (sIL-2R, IL-4, IL-6) was performed in 32 patients with schizophrenia (15 men and 17 women aged from 29 to 56 years) using the ELISA method. The evaluation was also performed in 32 healthy control subjects (16 men and 16 women aged from 23 to 61 years).

Results: Statistically significant differences were observed in lymphocyte subsets between schizophrenia patients and healthy control subjects (increase of CD19+, CD4/CD8 during exacerbation and increase of CD4/CD8 in remission). There were no significant differences between schizophrenic men and women in the above parameters during exacerbation and remission of schizophrenia. Statistically significant differences were observed in cytokine concentration between patients during acute episodes of schizophrenia and healthy control subjects (higher sIL-2R level), but not in remission. Also, there were significant differences between patients in exacerbation of schizophrenia and remission (higher IL-4 level).

Conclusions: The results obtained confirm changes of immune system activity in schizophrenia including both activation and suppression at the same time. This may suggest an immunological imbalance during schizophrenia.
keywords:

schizophrenia, cytokines, lymphocyte subsets

Quick links
© 2021 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe