Symptomatic treatment of insomnia is a daily practice for physicians across all medical specialties. Due to the significant risk of dependence associated with the use of benzodiazepine hypnotics and Z-drugs, there is growing interest in alternative and safer pharmacological options. One such agent is quetiapine, a drug with a wide therapeutic index, whose mechanism of action involves various receptors, depending on the dose administered. The authors present a literature review regarding the efficacy and tolerability of quetiapine in the symptomatic treatment of insomnia. They conclude that, despite substantial evidence supporting the effectiveness of quetiapine for insomnia symptoms, further research is still needed on the use of low-dose quetiapine in individuals who do not suffer from serious mental illnesses. Although low-dose quetiapine is generally well tolerated, caution should be applied when administering it to the elderly population.