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Advances in Interventional Cardiology
eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
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abstract:
Original paper

Plasma levels of NO-related pathway molecules to predict post-transcatheter aortic valve implantation major adverse cardiovascular events: a prospective, multicenter study

Aleksandra Gąsecka
1
,
Natalia Krajewska
1
,
Bogna Rajewska
1
,
Agata Suleja
1
,
Weronika Kisielewska
1
,
Michał Łomiak
1
,
Jan Budzianowski
2
,
Anna Olasińska-Wiśniewska
3
,
Janusz Kochman
1
,
Marcin Ufnal
4

  1. 1st Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, Poland
  2. Department of Interventional Cardiology and Cardiac Surgery, University of Zielona Góra, Collegium Medicum, Zielona Gora, Poland
  3. Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland
  4. Department of Experimental Physiology and Pathophysiology, Medical University of Warsaw, Warsaw, Poland
Adv Interv Cardiol
DOI: https://doi.org/10.5114/aic.2025.151798
Online publish date: 2025/06/04
View full text Get citation
 
Introduction:
Aortic stenosis (AS) is associated with alterations in the concentrations of nitric oxide (NO)-related pathway molecules, including arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA).

Aim:
We aimed to determine the effect of transcatheter aortic valve implantation (TAVI) on the concentrations of arginine, ADMA, and SDMA and to evaluate their predictive value for post-TAVI outcomes.

Material and methods:
In total, 128 patients with AS referred for TAVI were enrolled in the study. Blood samples were collected 1 day before TAVI and at hospital discharge. Concentrations of arginine, ADMA, and SDMA were measured using ultra performance liquid chromatography coupled with mass spectrometry.

Results:
Plasma concentrations of arginine, ADMA, and SDMA did not change after TAVI, compared to baseline (p ≥ 0.70 for all). The median time of follow-up was 13.5 months. Arginine, ADMA, and SDMA did not predict post-TAVI MACE during the follow-up time (p ≥ 0.88). There were significant negative correlations between the concentrations of ADMA and SDMA and echocardiographic parameters of AS severity before TAVI (p < 0.01 for all).

Conclusions:
Plasma concentrations of arginine, ADMA, and SDMA were not affected by TAVI and did not predict post-TAVI MACE. ADMA and SDMA negatively correlated with AS severity, which might indicate alterations in the NO/L-arginine pathway in patients with AS.

keywords:

aortic stenosis, arginine, asymmetric dimethylarginine, symmetric dimethylarginine, transcatheter aortic valve implantation
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