Advances in Interventional Cardiology
eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
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Original paper

Predictive value of circulating cardiomyocyte-specific cell-free DNA levels for heart failure risk after acute ST-segment elevation myocardial infarction

Yanling Feng
1
,
Yufeng Zhuo
1
,
Hongji Cheng
1

  1. Department of Cardiology, Panyu District He Xian Memorial Hospital, Guangzhou, China
Adv Interv Cardiol
DOI: https://doi.org/10.5114/aic.2025.156807
Online publish date: 2025/12/06
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10. Sorbini M, Carradori T, Togliatto GM, et al. Technical advances in circulating cell-free DNA detection and analysis for personalized medicine in patients’ care. Biomolecules 2024; 14: 498.
11. Lehmann-Werman R, Neiman D, Zemmour H, et al. Identification of tissue-specific cell death using methylation patterns of circulating DNA. Proc Natl Acad Sci USA 2016; 113: E1826-34.
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13. Guo S, Diep D, Plongthongkum N, et al. Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA. Nat Genet 2017; 49: 635-42.
14. Thygesen K, Alpert JS, Jaffe AS, et al. Third universal definition of myocardial infarction. Eur Heart J 2012; 33: 2551-67.
15. Authors/Task Force Members; McDonagh TA, Metra M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2022; 24: 4-131.
16. Hellermann JP, Jacobsen SJ, Gersh BJ, et al. Heart failure after myocardial infarction: a review. Am J Med 2002; 113: 324-30.
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18. Zemmour H, Planer D, Magenheim J, et al. Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA. Nat Commun 2018; 9: 1443.
19. Yokokawa T, Misaka T, Kimishima Y, et al. Clinical significance of circulating cardiomyocyte-specific cell-free DNA in patients with heart failure: a proof-of-concept study. Can J Cardiol 2020; 36: 931-5.
20. Antonatos D, Patsilinakos S, Spanodimos S, et al. Cell-free DNA levels as a prognostic marker in acute myocardial infarction. Ann N Y Acad Sci 2006; 1075: 278-81.
21. Cui M, Fan M, Jing R, et al. Cell-free circulating DNA: a new biomarker for the acute coronary syndrome. Cardiology 2013; 124: 76-84.
22. Shimony A, Zahger D, Gilutz H, et al. Cell free DNA detected by a novel method in acute ST-elevation myocardial infarction patients. Acute Card Care 2010; 12: 109-11.
23. Pieri M, Vayianos P, Nicolaidou V, et al. Alterations in circulating miRNA levels after infection with SARS-CoV-2 could contribute to the development of cardiovascular diseases: what we know so far. Int J Mol Sci 2023; 24: 2380.
Copyright: © 2025 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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