Introduction

In recent years, there has been rapid development of minimally invasive cardiovascular procedures, such as atrial septal defect (ASD) transcatheter closure. Many female patients of reproductive age have undergone this procedure, but evidence regarding pregnancy outcomes after transcatheter closure of ASD remains limited.

Aim

Our aim was to assess maternal and fetal outcomes and investigate the magnitude and determinants of obstetric complications in patients after transcatheter closure of an ASD.

Material and methods

We analyzed 130 women with an average age of 28.6 ±9.1 years (19–44) who underwent ASD transcatheter closure using the Amplatz Septal Occluder. Detailed records of each pregnancy (n = 130), occurring an average of 18.2 ±4.1 months (11–35) after transcatheter closure, were analyzed. Cardiac events were defined as heart failure exacerbation, stroke, transient ischemic attack (TIA), arrhythmias, or endocarditis; obstetric events as pregnancy-induced hypertension (PIH), preeclampsia, HELLP syndrome, premature labor, or postpartum hemorrhage; neonatal events as premature delivery, small-for-gestational age, or fetal or neonatal morbidity or mortality.

Results

Cardiac events were observed during 20.8% (n = 27) of pregnancies and included supraventricular arrhythmias (n = 24, 18.5%) and severe peripheral edema (n = 3, 2.3%). Obstetric events occurred in 22 (16.9%) patients. Neonatal events complicated only 2 (1.5%) pregnancies.

Conclusions

Most pregnancies after transcatheter ASD closure with the Amplatz Septal Occluder were completed successfully, with favorable obstetric and neonatal outcomes. Maternal complications were more common among women aged over 30 years.