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RESCUE-CD – Real-world effectiveness of risankizumab in moderate-to-severe Crohn’s disease: a case series involving the most refractory and challenging patients

Konrad Lewandowski
1
,
Katarzyna Karłowicz
1
,
Joanna Sarbinowska
2
,
Maciej Gonciarz
2
,
Dagmara Mahadea
3
,
Liliana Łykowska-Szuber
3
,
Piotr Eder
3
,
Anna Chaber-Ciopińska
4, 5
,
Edyta Zagórowicz
4, 5
,
Grażyna Rydzewska
1, 6

  1. Department of Gastroenterology and Internal Medicine, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland
  2. Department of Gastroenterology and Internal Medicine, Military Institute of Medicine – National Research Institute, Warsaw, Poland
  3. Department of Gastroenterology, Dietetics, and Internal Diseases, Poznan University of Medical Sciences, H. Święcicki University Hospital, Poznan, Poland
  4. Department of Oncological Gastroenterology, Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
  5. Department of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, Warsaw, Poland
  6. Collegium Medicum, Jan Kochanowski University, Kielce, Poland
Gastroenterology Rev
Data publikacji online: 2026/03/10
Plik artykułu:
- RESCUE-CD.pdf  [0.11 MB]
Pobierz cytowanie
 
Metryki PlumX:
 
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4. Kobayashi T, Okamoto S, Hisamatsu T, et al. IL-23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn’s disease. Gut 2008; 57: 1682-9.
5. Liu M, Zhu W, Wang J, et al. Interleukin-23 receptor genetic polymorphisms and ulcerative colitis susceptibility: a meta-analysis. Clin Res Hepatol Gastroenterol 2015; 39: 516-25.
6. Schmechel S, Konrad A, Diegelmann J, et al. Linking genetic susceptibility to Crohn’s disease with Th17 cell function: IL-22 serum levels are increased in Crohn’s disease and correlate with disease activity and IL23R genotype status. Inflamm Bowel Dis 2008; 14: 204-12.
7. Wolk K, Witte E, Hoffmann U, et al. IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn’s disease. J Immunol 2007; 178: 5973-81.
8. Brand S, Beigel F, Olszak T, et al. IL-22 is increased in active Crohn’s disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. Am J Physiol Gastrointest Liver Physiol 2006; 290: G827-38.
9. Sands BE, Chen J, Feagan BG, et al. Efficacy and safety of MEDI2070, an antibody against interleukin-23, in patients with moderate to severe Crohn’s disease: a phase 2a study. Gastroenterology 2017; 153: 77-86.e6.
10. D’Haens G, Panaccione R, Baert F, et al. Risankizumab as induction therapy for Crohn’s disease: results from the phase 3 ADVANCE and MOTIVATE induction trials. Lancet 2022; 399: 2015-30.
11. Feagan BG, Sandborn WJ, D’Haens G, et al. Induction therapy with the selective interleukin-23 inhibitor risankizumab in patients with moderate-to-severe Crohn’s disease: a randomised, double-blind, placebo-controlled phase 2 study. Lancet 2017; 389: 1699-709.
12. Wang SV, Pottegård A, Crown W, et al. Harmonized protocol template to enhance reproducibility of hypothesis evaluating real-world evidence studies on treatment effects: a good practices report of a joint ISPE/ISPOR task force. Pharmacoepidemiol Drug Saf 2023; 32: 44-55.
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