Recently, surgery followed by radiotherapy with temozolomide has become a standard treatment for glioblastoma patients. During chemoradiotherpy in one of our glioblastoma patients sudden respiratory failure resulted in death of the patient. CT scans and autopsy revealed multiorgan aspergillosis (brain, lungs) as a cause of death. Systemic aspergillosis should be suspected in glioblastoma patients treated with multimodality therapy with fever resistant to broad-spectrum antibiotics.